Other Ageing Factor: ERC release - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Other Ageing Factor Name | : | ERC release | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009154 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||
1 | OB_004749 | Saccharomyces cerevisiae | W303AR5 |
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decreased | -23.30% | 13.5 | 17.6 | mean | 30 | ℃ | mata | Release of an extrachromosomal rDNA circle (ERC) in virgin daughter cells shortened replicative life span. Deletion of SIR4 did not further shorten life span when an ERC was released. | Kaeberlein et al. | 1999 | 10521401 | Lifespan Observations Database (ID: 1781) | ||||||||||||||||||||||
2 | OB_000521 | Saccharomyces cerevisiae | W303AR5 |
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decreased | -26.14% | 13 | 17.6 | mean | 30 | ℃ | mata | Release of an extrachromosomal rDNA circle (ERC) in virgin daughter cells shortened replicative life span. Deletion of SIR4 did not further shorten life span when an ERC was released. | Kaeberlein et al. | 1999 | 10521401 | Lifespan Observations Database (ID: 1783) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, McVey M, Guarente L:
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
Genes Dev. 1999; 13: 2570-80.
PubMed (ID: 10521401), PubMed Central (ID: PMC317077)
MeSH Terms: DNA-Binding Proteins/physiology; Fungal Proteins/physiology; Histone Deacetylases; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/physiology; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/physiology