Other Ageing Factor: Irradiation - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Other Ageing Factor Name | : | Irradiation | ||||||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009157 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||
1 | OB_004756 | Mus musculus | AKR/J |
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increased | 5.65% | 243 | 230 | days | To evaluate the effect of low-dose-rate radiation on cancer incidence, short-lived AKR/J mice were housed in a long-term low-dose-rate irradiation facility ((137)Cs, 0.07 cGy/h). Thymic lymphoma incidence and life span were compared withmice irradiated at a high dose rate ((137)Cs, 0.8Gy/min, total dose of 4.5 Gy) and nonirradiated mice. The average life span of the low-dose-rate irradiated mice (243 days) was longer than those of the high-dose-rate irradiated mice (208 days) and nonirradiated mice (230 days) (P = 0.02). The incidence of thymic lymphoma in low-dose-rate irradiated mice was lower than that in nonirradiated mice and high-dose-rate irradiated mice by 10 and 20%, respectively (P < 0.01). | Shin et al. | 2010 | 20726732 | doi:10.1667/RR1946.1 | Lifespan Observations Database (ID: 1861) | ||||||||||
2 | OB_004757 | Mus musculus | AKR/J |
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decreased | -9.57% | 208 | 230 | days | To evaluate the effect of low-dose-rate radiation on cancer incidence, short-lived AKR/J mice were housed in a long-term low-dose-rate irradiation facility ((137)Cs, 0.07 cGy/h). Thymic lymphoma incidence and life span were compared withmice irradiated at a high dose rate ((137)Cs, 0.8Gy/min, total dose of 4.5 Gy) and nonirradiated mice. The average life span of the low-dose-rate irradiated mice (243 days) was longer than those of the high-dose-rate irradiated mice (208 days) and nonirradiated mice (230 days) (P = 0.02). The incidence of thymic lymphoma in low-dose-rate irradiated mice was lower than that in nonirradiated mice and high-dose-rate irradiated mice by 10 and 20%, respectively (P < 0.01). | Shin et al. | 2010 | 20726732 | doi:10.1667/RR1946.1 | Lifespan Observations Database (ID: 1862) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Shin SC, Kang YM, Kim HS:
Life span and thymic lymphoma incidence in high- and low-dose-rate irradiated AKR/J mice and commonly expressed genes.
Radiat Res. 2010; 174: 341-6.
PubMed (ID: 20726732), doi:10.1667/RR1946.1
MeSH Terms: Gene Expression Regulation, Neoplastic/radiation effects; Life Expectancy; Lymphoma/genetics; Thymus Neoplasms/genetics