1 |
OB_001119 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
osm-5 |
Caenorhabditis elegans |
180585 |
unknown |
p813 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
295.65% |
72.8 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2439) |
2 |
OB_001116 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-10 |
Caenorhabditis elegans |
184883 |
unknown |
m79 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
196.74% |
54.6 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2436) |
3 |
OB_001113 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
tax-4 |
Caenorhabditis elegans |
176297 |
unknown |
p678 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
107.06% |
38.1 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2433) |
4 |
OB_001363 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
78.26% |
36.9 |
20.7 |
days |
mean |
|
|
hermaphrodite |
Lifespan increased relative to daf-2(e1368) mutants (30.5 days) with intact gonads and to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2683) |
5 |
OB_001362 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
57.49% |
32.6 |
20.7 |
days |
mean |
|
|
hermaphrodite |
Lifespan increased relative to daf-2(e1368) mutants (31.4 days) with intact gonads and to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2682) |
6 |
OB_001106 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-6 |
Caenorhabditis elegans |
181584 |
unknown |
e1377 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
52.72% |
28.1 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2427) |
7 |
OB_001364 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
47.34% |
30.5 |
20.7 |
days |
mean |
|
|
hermaphrodite |
Lifespan decreased relative to daf-2(e1368) mutants (39.1 days) with intact gonad, increased to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2684) |
8 |
OB_001366 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cul-1 |
Caenorhabditis elegans |
176466 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
32.85% |
27.5 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNAi inactivation decreased lifespan relative to daf-2(e1368) mutants with and without intact gonad; lifespan still increased relative to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2686) |
9 |
OB_001110 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
osm-3 |
Caenorhabditis elegans |
177141 |
unknown |
n1540 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
30.98% |
24.1 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2430) |
10 |
OB_004352 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
22.84% |
19.9 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2314) |
11 |
OB_001365 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cul-1 |
Caenorhabditis elegans |
176466 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
19.81% |
24.8 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNAi inactivation decreased lifespan relative to daf-2(e1368) mutants with and without intact gonad; lifespan still increased relative to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2685) |
12 |
OB_000951 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-9 |
Caenorhabditis elegans |
180889 |
normal |
dh6;dhEx24 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
19.05% |
37.5 |
31.5 |
days |
max |
20 |
℃ |
hermaphrodite |
Ablation of the somatic gonadal precursors, Z1 and Z4, decreases the extension generated by germ cell ablation (Z2 and Z3 removal), suggesting that opposing signals from germline and somatic gonad could regulate longevity. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2259) |
13 |
OB_000929 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-9 |
Caenorhabditis elegans |
180889 |
loss of function |
dh6 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
17.92% |
25 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Additional removal of the somatic gonadal precursors, Z1 and Z4, in germline-deficient animals did not significantly change lifespan relative to control. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2237) |
14 |
OB_001007 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
unknown |
rh61rh411 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
13.61% |
16.7 |
14.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2325) |
15 |
OB_004350 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2,Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1,Z4 laser ablation at L1 larval stage |
|
increased |
11.76% |
20.9 |
18.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2306) |
16 |
OB_001367 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cul-1 |
Caenorhabditis elegans |
176466 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 gonad ablation |
|
increased |
11.11% |
23 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNAi inactivation had no significant difference on lifespan between daf-2(e1368) mutants with and without intact gonad; lifespan still increased relative to wild type. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2687) |
17 |
OB_000927 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-9 |
Caenorhabditis elegans |
180889 |
loss of function |
dh6;dhEx24 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
8.12% |
21.3 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Additional removal of the somatic gonadal precursors, Z1 and Z4, from germline-deficient animals abrogates the extension generated by Z2 and Z3 ablation, suggesting that opposing signals from germline and somatic gonad could regulate longevity. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2235) |
18 |
OB_004355 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
7.74% |
16.7 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2330) |
19 |
OB_004841 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
increased |
5.98% |
19.5 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. These mutations do not further extend long-lived daf-2 mutants |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2424) |
20 |
OB_001006 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
unknown |
rh61rh411 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
none |
-2.72% |
14.3 |
14.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2324) |
21 |
OB_004838 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-7.74% |
14.3 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2331) |
22 |
OB_000925 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
rh50 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-14.36% |
17.3 |
20.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Removal of the somatic gonadal precursors, Z1 and Z4, in germline-deficient animals decreases lifespan approximately 14%. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2233) |
23 |
OB_004825 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-14.81% |
18.4 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Additional removal of the somatic gonadal precursors, Z1 and Z4, abrogates the extension generated by Z2 and Z3 ablation, suggesting that opposing signals from germline and somatic gonad could regulate longevity. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2231) |
24 |
OB_004835 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-16.05% |
13.6 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2315) |
25 |
OB_001014 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-18.71% |
12.6 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2336) |
26 |
OB_001013 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-24.52% |
11.7 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2335) |
27 |
OB_004832 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-25.13% |
14 |
18.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2307) |