Other Ageing Factor: Environmental enrichment - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Other Ageing Factor Name | : | Environmental enrichment | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009171 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||
1 | OB_004831 | Mus musculus | ICR/CD-1 |
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increased | 6.52% | 686 | 644 | days | median | female | Environmental enrichment starting between 44-69 weeks of age increased life span and was efficient in improving the function (i.e., macrophage chemotaxis and phagocytosis, lymphocyte chemotaxis and proliferation, natural killer cell activity, interleukin-2 and tumor necrosis factor-alpha levels) and decreasing the oxidative-inflammatory stress (i.e., lowered oxidized glutathione content, xanthine oxidase activity, expression of Toll-like receptors 2 and 4 on CD4 and CD8 cells, and increased reduced glutathione and glutathione peroxidase and catalase activities) of immune cells. | Arranz et al. | 2010 | 20707722 | doi:10.1089/rej.2009.0989 | Lifespan Observations Database (ID: 2282) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M:
Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.
Rejuvenation Res. 2010; 13: 415-28.
PubMed (ID: 20707722), doi:10.1089/rej.2009.0989
MeSH Terms: Aging/immunology; Longevity