1 |
OB_002304 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
59.38% |
30.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 4.5-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3580) |
2 |
OB_002306 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
52.08% |
29.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 12-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3582) |
3 |
OB_002305 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
51.04% |
29 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 8-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3581) |
4 |
OB_002302 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
48.96% |
28.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 0-hours. (No induction; age-1 control). Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3579) |
5 |
OB_002309 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
35.94% |
26.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 12-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3585) |
6 |
OB_002310 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
30.73% |
25.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 24-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3586) |
7 |
OB_004848 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
27.60% |
24.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 12-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3544) |
8 |
OB_002308 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
21.88% |
23.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 6-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3584) |
9 |
OB_004850 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
15.15% |
15.2 |
13.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 12-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3577) |
10 |
OB_004846 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
15.10% |
22.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 4.5-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3542) |
11 |
OB_004849 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
11.36% |
14.7 |
13.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 6-hours. Worms were then returned to 20C for analysis of survival. Controls had no no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3576) |
12 |
OB_004847 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
10.42% |
21.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 8-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3543) |
13 |
OB_003179 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
loss of function |
rh273 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
Worms were transferred to new plates on day 2 of adulthood, shifted from 20 C to 35 C, and scored hourly for survival by touch provoked movement. |
|
increased |
10.00% |
11 |
10 |
|
mean |
|
|
hermaphrodite |
Mean lifespan of daf-12(rh273) mutants was extended approximately 10% relative to N2 following heat shock assay. |
Fisher et al. |
2006 |
16626392 |
doi:10.1111/j.1474-9726.2006.00203.x |
Lifespan Observations Database (ID: 4593) |
14 |
OB_004851 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
increased |
9.85% |
14.5 |
13.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 24-hours. Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3578) |
15 |
OB_002307 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
A transient exposure to nonlethal thermal stress. Animals were exposed to 30C for 3-24 hours then returned to 20C. |
|
none |
2.60% |
19.7 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Pretreatment induces thermotolerance and life-span extension in TJ1052 [age-1(hx546)II]. Thermotolerance was induced by exposing 4-day-old adult hermaphrodites to 30C for 0-hours. (No induction; age-1 control). Worms were then returned to 20C for analysis of survival. Controls had no pretreatment. |
Lithgow et al. |
1995 |
7638227 |
|
Lifespan Observations Database (ID: 3583) |
16 |
OB_003192 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
gst-10 |
Caenorhabditis elegans |
178725 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
For assessing heat resistance, young adult worms were incubated in 60-mm RNAi or +RNAi plates at 36 0.4 C. |
|
decreased |
-12.85% |
7.19 |
8.25 |
|
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown reduced daf-2(e1370) lifespan approximately 13% under heat shock conditions. |
Ayyadevara et al. |
2005 |
16300482 |
doi:10.1111/j.1474-9726.2005.00172.x |
Lifespan Observations Database (ID: 4604) |
17 |
OB_003191 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
gst-10 |
Caenorhabditis elegans |
178725 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
For assessing heat resistance, young adult worms were incubated in 60-mm RNAi or +RNAi plates at 36 0.4 C. |
|
decreased |
-14.98% |
5.79 |
6.81 |
|
mean |
20 |
℃ |
hermaphrodite |
ERNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown reduced lifespan approximately 15% under heat shock conditions. |
Ayyadevara et al. |
2005 |
16300482 |
doi:10.1111/j.1474-9726.2005.00172.x |
Lifespan Observations Database (ID: 4603) |
18 |
OB_003178 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
loss of function |
rhrh61rh411 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat shock |
Worms were transferred to new plates on day 2 of adulthood, shifted from 20 C to 35 C, and scored hourly for survival by touch provoked movement. |
|
decreased |
-15.00% |
8.5 |
10 |
|
mean |
|
|
hermaphrodite |
Mean lifespan of daf-12(rh61rh411) mutants was shortened approximately 15% relative to N2 following heat shock assay. |
Fisher et al. |
2006 |
16626392 |
doi:10.1111/j.1474-9726.2006.00203.x |
Lifespan Observations Database (ID: 4592) |