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Other Ageing Factor: Overfeeding - Caenorhabditis elegans

Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Ageing relevance by experimental analysis: yes
Defined by: Name
Ageing relevance by experimental analysis: yes
Defined by: Name

Summary

Other Ageing Factor Name : Overfeeding
Species : Caenorhabditis elegans
Ageing Relevance Analysis :
Observation Type Count Ageing Relevance Source
Ageing Phenotype Observation—Data Type 2
Lifespan Effect
decreased 1 yes (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
Total 1
Ageing Factor Stable ID : AF_009180
Download : [xml icon]XML

Observations

Ageing Phenotype

Data Type 1

no ageing phenotype observation—data type 1 available

Data Type 2

Ageing Relevance:
  • yes (Exp. Analysis)
  • yes, but no ageing factor assigned (Exp. Analysis)
  • no (Exp. Analysis)
  • putative (Comp. Analysis)
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
1 OB_002732 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
drr-2 Caenorhabditis elegans 259546 over-expression EQ19 unknown unknown
Other Ageing Factor Name Additional Information
Overfeeding 1 x 10^12 cells/mL. A 10-fold increase from control. UV-killed E. coli food source.
decreased -9.25% 15.7 17.3 days mean 20 ℃ hermaphrodite Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. Ching et al. 2010 20456299 [DOI icon]doi:10.1111/j.1474-9726.2010.00580.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 4026)
2 OB_004863 Caenorhabditis elegans N2
Other Ageing Factor Name Additional Information
Overfeeding 1 x 10^12 cells/mL. A 10-fold increase from control. UV-killed E. coli food source.
decreased -10.40% 15.5 17.3 days mean 20 ℃ hermaphrodite Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. Ching et al. 2010 20456299 [DOI icon]doi:10.1111/j.1474-9726.2010.00580.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 4027)
3 OB_002733 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-16 Caenorhabditis elegans 172981 deletion / null mu86 unknown unknown
Other Ageing Factor Name Additional Information
Overfeeding 1 x 10^12 cells/mL. A 10-fold increase from control. UV-killed E. coli food source.
decreased -30.06% 12.1 17.3 days mean 20 ℃ hermaphrodite Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. Ching et al. 2010 20456299 [DOI icon]doi:10.1111/j.1474-9726.2010.00580.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 4028)

Homology Analysis

no homology analysis observation available

References

MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.

  1. Ching TT, Paal AB, Mehta A, Zhong L, Hsu AL:
    drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans.
    Aging Cell. 2010; 9: 545-57.
    [PubMed icon]PubMed (ID: 20456299), [PubMed icon]PubMed Central (ID: PMC2910166), [DOI icon]doi:10.1111/j.1474-9726.2010.00580.x
    MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Caloric Restriction; Diet; Eukaryotic Initiation Factors/metabolism; Longevity/physiology; Phosphotransferases (Alcohol Group Acceptor)/metabolism

Sources

Ageing-related Data Sources

Additional Data Sources