1 |
OB_005000 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Comaparison of N2 lifespan at 20 degrees ("wild-type" control condition) versus 16 degrees centigrade. |
|
increased |
56.35% |
19.7 |
12.6 |
days |
median |
16 |
℃ |
|
Comaparison of N2 lifespan at 20 degrees ("wild-type" control condition) versus 16 degrees centigrade. |
Hosono et al. |
1982 |
6213421 |
|
Lifespan Observations Database (ID: 5254) |
2 |
OB_004922 |
Saccharomyces cerevisiae |
YPK9 |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for the first 7 divisions to act as a control for strain CS16, which has a temperature sensitive mutation in ATP2. Cells were then switched to 30 degrees for the remainder of the lifespan. |
|
increased |
34.09% |
17.7 |
13.2 |
divisions |
mean |
|
|
mata |
After 7 divisions, the remaining lifespan of a newly divided daughter cell is 34.1% longer than that of the mother cell when the cell is able to undergo asymmetric division. |
Lai et al. |
2002 |
12242224 |
|
Lifespan Observations Database (ID: 4478) |
3 |
OB_003162 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
or178 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Eggs to L4 molt were maintained at 15 degrees Celsius, then moved to 20 degrees Celsius during adulthood. |
|
increased |
27.57% |
23.6 |
18.5 |
days |
mean |
20 |
℃ |
|
Mean lifespan of mutant glp-1(or178) was extended approximately 28% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4555) |
4 |
OB_003163 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
or178 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Eggs to L4 molt were maintained at 15 degrees Celsius, then moved to 20 degrees Celsius during adulthood. |
|
increased |
16.22% |
21.5 |
18.5 |
days |
mean |
20 |
℃ |
|
Mean lifespan of double mutant glp-1(or178); aak-2(ok524) was extended approximately 16% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4556) |
5 |
OB_004928 |
Nothobranchius furzeri |
|
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
A total of 256 Nothobranchius furzeri were hatched and raised at the standard temperature of 25 C. At age 4 weeks, when the fish are sexually mature they were divided into two groups. One group of 145 (for a total of five independent trials) remained at 25C and a group of 101 fishes (for a total of two independent trials) was moved to 22C. |
|
increased |
13.64% |
12.5 |
11 |
|
max |
|
|
|
Reducing environmental temperature by 3 degrees extended maximum lifespan approximately 14%. |
Valenzano et al. |
2006 |
16842500 |
doi:10.1111/j.1474-9726.2006.00212.x |
Lifespan Observations Database (ID: 4542) |
6 |
OB_004927 |
Nothobranchius furzeri |
|
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
A total of 256 Nothobranchius furzeri were hatched and raised at the standard temperature of 25 C. At age 4 weeks, when the fish are sexually mature they were divided into two groups. One group of 145 (for a total of five independent trials) remained at 25C and a group of 101 fishes (for a total of two independent trials) was moved to 22C. |
|
increased |
11.11% |
10 |
9 |
|
median |
|
|
|
Reducing environmental temperature by 3 degrees extended mean lifespan approximately 11%. |
Valenzano et al. |
2006 |
16842500 |
doi:10.1111/j.1474-9726.2006.00212.x |
Lifespan Observations Database (ID: 4541) |
7 |
OB_003097 |
Saccharomyces cerevisiae |
CS16 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ATP2 |
Saccharomyces cerevisiae |
853585 |
loss of function |
G325A |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for the first 7 divisions to deactivate atp2 and activate the clonal senescence phenotype. Cells were then switched to 30 degrees for the remainder of the lifespan. |
|
none |
-4.32% |
13.3 |
13.9 |
divisions |
mean |
|
|
mata |
Preventing asymmetric division by deactivation of ATP2 results in mother and daughter cells with equivalent remaining replicative lifespan. |
Lai et al. |
2002 |
12242224 |
|
Lifespan Observations Database (ID: 4477) |
8 |
OB_003072 |
Saccharomyces cerevisiae |
124 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC24 |
Saccharomyces cerevisiae |
851190 |
loss of function |
cdc24-1 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for 2 hours prior to life measurement to deactivate cdc24 and induce chitin accumulation. |
|
decreased |
-8.33% |
11 |
12 |
divisions |
mean |
|
|
mata |
Chitin accumulation does not affect lifespan. Yeast accumulate chitin in bud scars with replicative age. Cells lacking cdc24 randomly accumulate chitin in the cell wall. Two hour accumulation of chitin by temperature-induced deactivation of cdc24-1, which results in 5-10 fold increased accumultion of chitin, does not affect replicative lifespan. |
Egilmez et al. |
1989 |
2644196 |
|
Lifespan Observations Database (ID: 4442) |
9 |
OB_003078 |
Saccharomyces cerevisiae |
124 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC24 |
Saccharomyces cerevisiae |
851190 |
loss of function |
cdc24-1 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for 2 hours prior to life measurement to deactivate cdc24 and induce chitin accumulation. |
|
decreased |
-8.33% |
11 |
12 |
divisions |
mean |
|
|
mata |
Chitin accumulation does not affect lifespan. Yeast accumulate chitin in bud scars with replicative age. Cells lacking cdc24 randomly accumulate chitin in the cell wall. Two hour accumulation of chitin by temperature-induced deactivation of cdc24-1, which results in 5-10 fold increased accumultion of chitin, does not affect replicative lifespan. |
Jazwinski et al. |
1989 |
2698814 |
|
Lifespan Observations Database (ID: 4449) |
10 |
OB_003161 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Eggs to L4 molt were maintained at 15 degrees Celsius, then moved to 20 degrees Celsius during adulthood. |
|
decreased |
-13.51% |
16 |
18.5 |
|
mean |
20 |
℃ |
|
Mean lifespan of mutant aak-2(ok524) was shortened approximately 14% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4554) |
11 |
OB_003073 |
Saccharomyces cerevisiae |
182-6-3 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC7 |
Saccharomyces cerevisiae |
851545 |
loss of function |
cdc7-1 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for 2 hours prior to life measurement to deactivate cdc7 . |
|
decreased |
-30.77% |
9 |
13 |
divisions |
mean |
|
|
mata |
Two-hour , temperature-induced deactivation of cdc7-1 decreases replicative lifespan by 30.8%. Cells lacking functional cdc7 have arrested cell cycle, but do not accumulate chitin in the cell wall. |
Egilmez et al. |
1989 |
2644196 |
|
Lifespan Observations Database (ID: 4443) |
12 |
OB_003080 |
Saccharomyces cerevisiae |
182-6-3 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC7 |
Saccharomyces cerevisiae |
851545 |
loss of function |
cdc7-1 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
Cells exposed to 36 degrees C for 2 hours prior to life measurement to deactivate cdc7 . |
|
decreased |
-30.77% |
9 |
13 |
divisions |
mean |
|
|
mata |
Two-hour , temperature-induced deactivation of cdc7-1 decreases replicative lifespan by 30.8%. Cells lacking functional cdc7 have arrested cell cycle, but do not accumulate chitin in the cell wall. |
Jazwinski et al. |
1989 |
2698814 |
|
Lifespan Observations Database (ID: 4450) |
13 |
OB_004999 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Temperature |
"WT" lifespan in this case refers to N2 lifespan at 20 degrees, the control condition. Lifespan observation reported here is for N2 lifespan at 25 degrees. |
|
decreased |
-34.92% |
8.2 |
12.6 |
days |
median |
25 |
℃ |
|
"WT" lifespan in this case refers to N2 lifespan at 20 degrees, the control condition. Lifespan observation reported here is for N2 lifespan at 25 degrees. |
Hosono et al. |
1982 |
6213421 |
|
Lifespan Observations Database (ID: 5253) |