1 |
OB_003166 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
123.08% |
58 |
26 |
days |
median |
20 |
℃ |
|
DR-FD does not require daf-16 and is additive with daf-2. DR-FD further increases the long lifespan of daf-2(e1370) mutants. Median lifespans: N2 Fed, 19 days; N2 DR-FD, 26 days; daf-2 Fed, 39 days; daf-2 DR-FD, 58 days. DR of daf-2 mutant is extended by approximately 123% relative to DR of N2. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4562) |
2 |
OB_004932 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
75.00% |
35 |
20 |
days |
median |
20 |
℃ |
|
Lifespan extension from DR-FD is decreased when DR-FD is initiated at the L4 stage compared to DR-FD initiated at the second day of adulthood or the eighth day of adulthood. Median lifespans: N2 Fed, 20 days; L4 DR-FD, 23 days; 2d adult DR-FD, 35 days; 8d adult DR-FD, 35 days. Lifespan of 2day and 8day adult-initiated caloric restriction is extended 75% relative to control. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4560) |
3 |
OB_004930 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
57.89% |
30 |
19 |
days |
median |
20 |
℃ |
|
Absence of bacterial food source during adulthood increases lifespan by approximately 58%. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4558) |
4 |
OB_004933 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
50.00% |
33 |
22 |
days |
median |
20 |
℃ |
|
Lifespan extension from DR-FD is independent of fecundity. DR-FD initiated at the 10th day of adulthood, after N2 hermaphrodites no longer produce eggs (N2 postreproductive DR-FD), increases lifespan by approximately 50% relative to control-fed (N2 Fed) animals. Median lifespans: N2 Fed, 22 days; N2 postreproductive DR-FD, 33 days. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4564) |
5 |
OB_003165 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m27 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
34.62% |
35 |
26 |
days |
median |
20 |
℃ |
|
DR-FD does not require daf-16 and is additive with daf-2. DR-FD increases the lifespan of daf-16(m27) mutants. Median lifespans: N2 Fed, 19 days; N2 DR-FD, 26 days; daf-16 Fed, 16 days; daf-16 DR-FD, 23 days. Dietary restriction of daf-16 increases lifespan 35% relative to N2 restricted. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4561) |
6 |
OB_004929 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
90% reduction in bacterial food. |
|
increased |
21.05% |
23 |
19 |
days |
median |
20 |
℃ |
|
Absence of bacterial food source (90%) during adulthood increases lifespan by approximately 21%. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4557) |
7 |
OB_004931 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
15.00% |
23 |
20 |
days |
median |
20 |
℃ |
|
Lifespan extension from DR-FD is decreased when DR-FD is initiated at the L4 stage compared to DR-FD initiated at the second day of adulthood or the eighth day of adulthood. Median lifespans: N2 Fed, 20 days; L4 DR-FD, 23 days; 2d adult DR-FD, 35 days; 8d adult DR-FD, 35 days. Lifespan of L4 initiated caloric restriction is extended 15% relative to control. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4559) |
8 |
OB_004926 |
Mus musculus |
wild |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Animals in the CR group were gradually restricted in 10% weekly increments from the previously calculated AL rate beginning at 3 months of age. Thus, at 13 weeks they were consuming 90% AL, at 14 weeks 80% AL, and so on, such that by 4 months of age, each CR animal was consuming 60% the AL amount. During the 7-day feeding trial, mice averaged 2.86 0.22 g (= 11.66 0.88 kcal) consumption per day. Thus CR mice received 1.72 0.14 g (= 6.41 0.48 kcal) per day. This represents a 40% reduction in amount eaten and a 45% reduction in calories. |
|
increased |
14.11% |
1601 |
1403 |
days |
max |
|
|
|
There was no significant difference in average lifespan of caloric restricted wild house mice relative to ad libitum. The longest lived CR mouse lived approximately 14% longer than the longest lived AL mouse. |
Harper et al. |
2006 |
17054664 |
doi:10.1111/j.1474-9726.2006.00236.x |
Lifespan Observations Database (ID: 4540) |
9 |
OB_003168 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
7.69% |
28 |
26 |
days |
median |
20 |
℃ |
|
Lifespan extension from DR-FD is independent of sir-2.1. DR-FD increases the lifespan of sir-2.1(ok434) deletion mutants to the same extent as N2 animals. Median lifespans: N2 Fed, 19 days; N2 DR-FD, 26 days; sir-2.1 Fed, 18 days; sir-2.1 DR-FD, 28 days. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4565) |
10 |
OB_003167 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
none |
0.00% |
35 |
35 |
days |
median |
20 |
℃ |
|
DR-FD and mutation of eat-2 increase lifespan and thermotolerance by similar mechanisms. DR-FD increases the lifespan of eat-2(ad465) mutants, but not beyond that of wild-type. Median lifespans: N2 Fed, 25 days; N2 DR-FD, 35 days; eat-2 Fed, 29 days; eat-2 DR-FD, 35 days. There is no significant difference in DR in lifespan of eat-2 mutants and N2. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4563) |
11 |
OB_004925 |
Mus musculus |
wild |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Animals in the CR group were gradually restricted in 10% weekly increments from the previously calculated AL rate beginning at 3 months of age. Thus, at 13 weeks they were consuming 90% AL, at 14 weeks 80% AL, and so on, such that by 4 months of age, each CR animal was consuming 60% the AL amount. During the 7-day feeding trial, mice averaged 2.86 0.22 g (= 11.66 0.88 kcal) consumption per day. Thus CR mice received 1.72 0.14 g (= 6.41 0.48 kcal) per day. This represents a 40% reduction in amount eaten and a 45% reduction in calories. |
|
none |
-2.01% |
870.6 |
888.5 |
days |
mean |
|
|
|
There was no significant difference in average lifespan of caloric restricted wild house mice relative to ad libitum. |
Harper et al. |
2006 |
17054664 |
doi:10.1111/j.1474-9726.2006.00236.x |
Lifespan Observations Database (ID: 4539) |
12 |
OB_003169 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
decreased |
-5.13% |
37 |
39 |
days |
median |
20 |
℃ |
|
Lifespan extension from DR-FD is independent of sir-2.1. DR-FD increases the lifespan if sir-2.1(ok434) eat-2(ad-465) double mutants to the same extent as N2 animals. Median lifespans: N2 Fed, 26 days, N2 DR-FD, 39 days; sir-2.1 eat-2, 28 days; sir-2.1 eat-2 DR-FD, 37 days. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4566) |