1 |
OB_004948 |
Caenorhabditis elegans |
sir-2(ok434) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
122.00% |
|
|
days |
max |
|
|
|
DD initiated at adult day 2 extended both mean and maximum lifespan in sir-2.1(ok434) worms by 81.8% (P < 0.0001) and 121.8% (P < 0.0001), respectively, compared to AL. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4581) |
2 |
OB_004949 |
Caenorhabditis elegans |
sir-2(ok434) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
82.00% |
|
|
days |
mean |
|
|
|
DD initiated at adult day 2 extended both mean and maximum lifespan in sir-2.1(ok434) worms by 81.8% (P < 0.0001) and 121.8% (P < 0.0001), respectively, compared to AL. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4582) |
3 |
OB_004952 |
Caenorhabditis elegans |
daf-16(mgDf50) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
64.00% |
|
|
days |
max |
|
|
|
Dietary deprivation (DD) increased lifespan of strains with defective insulin-like signaling. DD initiated at adult day 2 extended both mean and maximum lifespan in daf-16(mgDf50) worms by 62.3% (P < 0.0001) and 64.4% (P < 0.0001), respectively, compared to AL. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4585) |
4 |
OB_004953 |
Caenorhabditis elegans |
daf-16(mgDf50) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
62.00% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) increased lifespan of strains with defective insulin-like signaling. DD initiated at adult day 2 extended both mean and maximum lifespan in daf-16(mgDf50) worms by 62.3% (P < 0.0001) and 64.4% (P < 0.0001), respectively, compared to AL. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4586) |
5 |
OB_004937 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
42.48% |
21.8 |
15.3 |
days |
mean |
|
|
|
Mean lifespan of fem-1 (hc17) worms transferred to plates without food at day 2 of adulthood was 42% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4570) |
6 |
OB_004969 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
increased |
41.18% |
24 |
17 |
days |
median |
20 |
℃ |
|
Median lifespan under dietary deprivation was approximately 41% longer than control, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5019) |
7 |
OB_004968 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
increased |
40.24% |
23.7 |
16.9 |
days |
mean |
20 |
℃ |
|
Loss of trx-1 almost completely suppressed the lifespan extension caused by DD. Mean lifespan under dietary deprivation was approximately 40% longer than control, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5018) |
8 |
OB_004944 |
Caenorhabditis elegans |
mev-1(kn1) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
35.70% |
|
|
days |
mean |
20 |
℃ |
|
Dietary deprivation (DD) enhanced stress resistance. DD increased mean and maximum lifespan of mev-1(kn1) worms, which experienced increased oxidative stress. DD was initiated at adult day 3; increased mean lifespan by 35.7% |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4577) |
9 |
OB_004935 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
35.56% |
24.4 |
18 |
days |
max |
|
|
|
Maximum lifespan of fem-1 (hc17) worms without food was 36% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4568) |
10 |
OB_004950 |
Caenorhabditis elegans |
daf-2(e1370) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
35.00% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) increased lifespan of strains with defective insulin-like signaling. DD initiated at adult day 5 extended both mean and maximum lifespan of daf-2(e1370) worms by 35.2% (P < 0.0001) and 30.7% (P < 0.0001), respectively, compared to ad libitum (AL); |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4583) |
11 |
OB_004938 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
32.88% |
19.4 |
14.6 |
days |
mean |
|
|
|
Mean lifespan of fem-1 (hc17) worms transferred to plates without food at day 4 of adulthood was 33% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4571) |
12 |
OB_004951 |
Caenorhabditis elegans |
daf-2(e1370) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
31.00% |
|
|
days |
max |
|
|
|
Dietary deprivation (DD) increased lifespan of strains with defective insulin-like signaling. DD initiated at adult day 5 extended both mean and maximum lifespan of daf-2(e1370) worms by 35.2% (P < 0.0001) and 30.7% (P < 0.0001), respectively, compared to ad libitum (AL); |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4584) |
13 |
OB_004934 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
30.50% |
18.4 |
14.1 |
days |
mean |
|
|
|
Fem-1 (hc17) worms without food lived 30% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4567) |
14 |
OB_004942 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
Oxidative stress |
Adult day 3 worms transferred to paraquat (2.5M). |
|
increased |
29.50% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) enhanced stress resistance. DD enhanced resistance to oxidative stress from paraquat. Adult day 3 fem-1(hc17) worms were transferred to DD or ad libitum (AL) conditions with 2.5 or 6.25 M paraquat. DD increased mean and maximum survival on both paraquat concentrations, 2.5 M paraquat, 29.5% increased mean survival; 6.25 M paraquat, 26.1% increase. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4575) |
15 |
OB_004946 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
28.80% |
|
|
days |
mean |
|
|
|
DD did not lengthen mean or maximum lifespan in slow-feeding fem-1(hc17); eat-2(ad465) worms, which are subject to DR, although DD significantly increased both mean and maximum lifespan in the fem-1(hc17) single mutant by 28.8% (P < 0.0001) and 25.2% (P < 0.01), respectively. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4579) |
16 |
OB_004936 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
27.89% |
24.427 |
19.1 |
days |
max |
|
|
|
Maximum lifespan of fem-1 (hc17) worms transferred to plates without food at day 2 of adulthood was 28% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4569) |
17 |
OB_004943 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
Oxidative stress |
Adult day 3 worms transferred to paraquat (6.25M). |
|
increased |
26.10% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) enhanced stress resistance. DD enhanced resistance to oxidative stress from paraquat. Adult day 3 fem-1(hc17) worms were transferred to DD or ad libitum (AL) conditions with 2.5 or 6.25 M paraquat. DD increased mean and maximum survival on both paraquat concentrations, 2.5 M paraquat, 29.5% increased mean survival; 6.25 M paraquat, 26.1% increase. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4576) |
18 |
OB_004947 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
25.20% |
|
|
days |
max |
|
|
|
DD did not lengthen mean or maximum lifespan in slow-feeding fem-1(hc17); eat-2(ad465) worms, which are subject to DR, although DD significantly increased both mean and maximum lifespan in the fem-1(hc17) single mutant by 28.8% (P < 0.0001) and 25.2% (P < 0.01), respectively. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4580) |
19 |
OB_004939 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
24.50% |
24.9 |
20 |
days |
max |
|
|
|
Maximum lifespan of fem-1 (hc17) worms transferred to plates without food at day 4 of adulthood was 25% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4572) |
20 |
OB_004970 |
Caenorhabditis elegans |
N2 |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
increased |
19.23% |
31 |
26 |
days |
max |
20 |
℃ |
|
Maximum lifespan under dietary deprivation was approximately 19% longer than control, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5020) |
21 |
OB_004940 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
17.95% |
23 |
19.5 |
days |
max |
|
|
|
Maximum lifespan of fem-1 (hc17) worms transferred to plates without food at day 8 of adulthood was 18% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4573) |
22 |
OB_004941 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
increased |
13.55% |
17.6 |
15.5 |
days |
mean |
|
|
|
Mean lifespan of fem-1 (hc17) worms transferred to plates without food at day 8 of adulthood was 14% longer than those with food. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4574) |
23 |
OB_004945 |
Caenorhabditis elegans |
fem-1(hc17);eat-2(ad465) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
|
none |
0.00% |
32 |
32 |
days |
mean |
|
|
|
DD did not lengthen mean or maximum lifespan in slow-feeding fem-1(hc17); eat-2(ad465) worms, which are subject to DR, although DD significantly increased both mean and maximum lifespan in the fem-1(hc17) single mutant by 28.8% (P < 0.0001) and 25.2% (P < 0.01), respectively. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4578) |
24 |
OB_003585 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
trx-1 |
Caenorhabditis elegans |
181863 |
loss of function |
ok1449 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
decreased |
-7.69% |
24 |
26 |
days |
max |
20 |
℃ |
|
Loss of trx-1 almost completely suppressed the lifespan extension caused by DD. Maximum lifespan under dietary deprivation was approximately 7% shorter than control, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5021) |
25 |
OB_003587 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
trx-1 |
Caenorhabditis elegans |
181863 |
loss of function |
ok1449 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
decreased |
-22.49% |
13.1 |
16.9 |
days |
mean |
20 |
℃ |
|
Loss of trx-1 almost completely suppressed the lifespan extension caused by DD. Mean lifespan under dietary deprivation was approximately 24% shorter than control N2, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5023) |
26 |
OB_003586 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
trx-1 |
Caenorhabditis elegans |
181863 |
loss of function |
ok1449 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Without food source |
|
decreased |
-23.53% |
13 |
17 |
days |
median |
20 |
℃ |
|
Loss of trx-1 almost completely suppressed the lifespan extension caused by DD. Median lifespan under dietary deprivation was approximately 24% shorter than control, ad libitum. |
Fierro-González et al. |
2011 |
21334311 |
doi:10.1016/j.bbrc.2011.02.079 |
Lifespan Observations Database (ID: 5022) |