1 |
OB_003176 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
loss of function |
rh273 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
3-day-old adult hermaphrodite worms were immersed in S-basal containing a final concentration of 250 mM paraquat. |
|
increased |
33.33% |
6 |
4.5 |
|
mean |
20 |
℃ |
hermaphrodite |
Mean lifespan of daf-12(rh273) was extended approximately 33% relative to N2 following oxidative stress assay. |
Fisher et al. |
2006 |
16626392 |
doi:10.1111/j.1474-9726.2006.00203.x |
Lifespan Observations Database (ID: 4590) |
2 |
OB_003474 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
10 mM hydrogen peroxide diluted in S buffer |
|
increased |
30.00% |
3.9 |
3 |
|
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1368) mutant under oxidative stress was 30% longer than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4900) |
3 |
OB_004942 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
Oxidative stress |
Adult day 3 worms transferred to paraquat (2.5M). |
|
increased |
29.50% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) enhanced stress resistance. DD enhanced resistance to oxidative stress from paraquat. Adult day 3 fem-1(hc17) worms were transferred to DD or ad libitum (AL) conditions with 2.5 or 6.25 M paraquat. DD increased mean and maximum survival on both paraquat concentrations, 2.5 M paraquat, 29.5% increased mean survival; 6.25 M paraquat, 26.1% increase. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4575) |
4 |
OB_004943 |
Caenorhabditis elegans |
fem-1(hc17) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary deprivation |
Adult worms transferred to plates without food. |
Oxidative stress |
Adult day 3 worms transferred to paraquat (6.25M). |
|
increased |
26.10% |
|
|
days |
mean |
|
|
|
Dietary deprivation (DD) enhanced stress resistance. DD enhanced resistance to oxidative stress from paraquat. Adult day 3 fem-1(hc17) worms were transferred to DD or ad libitum (AL) conditions with 2.5 or 6.25 M paraquat. DD increased mean and maximum survival on both paraquat concentrations, 2.5 M paraquat, 29.5% increased mean survival; 6.25 M paraquat, 26.1% increase. |
Lee et al. |
2006 |
17096674 |
doi:10.1111/j.1474-9726.2006.00241.x |
Lifespan Observations Database (ID: 4576) |
5 |
OB_004975 |
Drosophila melanogaster |
Oregon-R-C (OR) |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary enhancement |
Apple polyphenols (AP) at various concentrations. |
Oxidative stress |
After 2 h of starvation, were transferred into vials containing a filter paper that was saturated with 1 mL of 20 mM paraquat in a 6% glucose solution. After 24 h, flies were moved to new vials containing only a water-saturated filter paper for 2 h before they were transferred back into vials containing respective diets. |
|
increased |
25.81% |
39 |
31 |
days |
max |
25 |
℃ |
|
Maximum lifespan of flies supplemented with 10 mg/ml AP (apple polyphenols) was approximately 16% longer than controls after exposure to paraquat stress. |
Peng et al. |
2011 |
21319854 |
doi:10.1021/jf1046267 |
Lifespan Observations Database (ID: 5049) |
6 |
OB_003634 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
oxy-5 |
Caenorhabditis elegans |
|
loss of function |
qa5002 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
Low oxygen environment, 1% relative to normal 21% oxygen. |
|
increased |
12.50% |
18 |
16 |
|
mean |
|
|
|
Under low air (1% oxygen) environment, mean lifespan of oxy-5(qa5002) mutant was approximately 10% longer than N2 control. |
Fujii et al. |
2011 |
21156009 |
doi:10.1111/j.1365-2443.2010.01469.x |
Lifespan Observations Database (ID: 5095) |
7 |
OB_003476 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
prmt-1 |
Caenorhabditis elegans |
180326 |
loss of function |
ok2710 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
10 mM hydrogen peroxide diluted in S buffer |
|
increased |
10.00% |
3.3 |
3 |
|
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1368);prmt-1(ok2710) mutant under oxidative stress was 10% longer than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4902) |
8 |
OB_003475 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
10 mM hydrogen peroxide diluted in S buffer |
|
decreased |
-10.00% |
2.7 |
3 |
|
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1368);daf-16(mu86) mutant under oxidative stress was 10% shorter than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4901) |
9 |
OB_003177 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-12 |
Caenorhabditis elegans |
181263 |
loss of function |
rhrh61rh411 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
3-day-old adult hermaphrodite worms were immersed in S-basal containing a final concentration of 250 mM paraquat. |
|
decreased |
-11.11% |
4 |
4.5 |
|
mean |
20 |
℃ |
hermaphrodite |
Mean lifespan of daf-12(rh61rh411) was shortened approximately 11% relative to N2 following oxidative stress assay. |
Fisher et al. |
2006 |
16626392 |
doi:10.1111/j.1474-9726.2006.00203.x |
Lifespan Observations Database (ID: 4591) |