1 |
OB_003421 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
175.32% |
362.6 |
131.7 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(e1370) mutant was approximately 175% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4846) |
2 |
OB_003422 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1371 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
153.84% |
343.7 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(e1371) mutant was approximately 154% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4847) |
3 |
OB_003423 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1371 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
106.20% |
279.2 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(e1371) mutant was approximately 106% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4848) |
4 |
OB_003428 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
sa187 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
92.25% |
260.3 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(sa187) mutant was approximately 92% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4852) |
5 |
OB_003424 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1391 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
73.56% |
235 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(e1391) mutant was approximately 74% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4849) |
6 |
OB_003426 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
m41 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
50.22% |
203.4 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(m41) mutant was approximately 50% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4850) |
7 |
OB_003427 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
m577 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
49.34% |
202.2 |
135.4 |
|
mean |
25 |
℃ |
|
Lifespan of daf-2(m577) mutant was approximately 50% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4851) |
8 |
OB_003420 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
hx546 |
unknown |
unknown |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
46.92% |
193.5 |
131.7 |
|
mean |
25 |
℃ |
|
Lifespan of age-1(hx546) mutant was approximately 47% longer than N2 control on cdc-25.1 RNAi background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4845) |
9 |
OB_003412 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
akt-1 |
Caenorhabditis elegans |
179424 |
loss of function |
ok525 |
unknown |
unknown |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
36.05% |
143.8 |
105.7 |
|
mean |
25 |
℃ |
|
akt-1 enhanced resistance to pathogens; lifespan was approximately 36% longer than N2 controls. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4838) |
10 |
OB_003413 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
akt-1 |
Caenorhabditis elegans |
179424 |
loss of function |
ok525 |
unknown |
unknown |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
increased |
25.45% |
132.6 |
105.7 |
|
mean |
25 |
℃ |
|
RNAi knockdown of cdc25.1 Glp in akt-2 enhanced resistance to pathogens; lifespan was approximately 25% longer than N2 controls. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4839) |
11 |
OB_003415 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
pdk-1 |
Caenorhabditis elegans |
180475 |
loss of function |
sa680 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
4.12% |
118.9 |
114.2 |
|
mean |
25 |
℃ |
|
The long-lived loss-of-function mutant pdk-1(sa680) also had wildtype-like survival on PA14 in a cdc-25.1 RNAi Glp background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4840) |
12 |
OB_003419 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
jnk-1 |
Caenorhabditis elegans |
177460 |
loss of function |
km2 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
2.62% |
117.3 |
114.3 |
|
mean |
25 |
℃ |
|
There was no significant difference in lifespan of jnk-1(km2) mutant than N2 control on cdc-25.1 background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4844) |
13 |
OB_003416 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
2.18% |
140.6 |
137.6 |
|
mean |
25 |
℃ |
|
Pathogen resistance is not linked with lifespan extension in aging mutants. There was no significant difference in lifespan of eat-2(ad465) mutant on cdc-25.1 Glp background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4841) |
14 |
OB_003408 |
Caenorhabditis elegans |
pha-1(e2123) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
1.57% |
45.2 |
44.5 |
|
mean |
25 |
℃ |
|
Daf-16 RNAi knock-down in sterile animals with intact germline proliferation, pha-1(e2123), resulted in survival kinetics that was indistinguishable from control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4834) |
15 |
OB_003418 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
jnk-1 |
Caenorhabditis elegans |
177460 |
loss of function |
gk7 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
0.17% |
114.5 |
114.3 |
|
mean |
25 |
℃ |
|
There was no significant difference in lifespan of jnk-1(gk7) mutant than N2 control on cdc-25.1 background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4843) |
16 |
OB_003409 |
Caenorhabditis elegans |
glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
-3.11% |
81.1 |
83.7 |
|
mean |
25 |
℃ |
|
Cdc-25.1 did not affect pathogen resistance beyond that observed in other Glp animals; glp-4(bn2) germline-deficient animals treated with cdc-25.1 dsRNA had similar survival kinetics on PA14 compared to those treated with vector control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4835) |
17 |
OB_003411 |
Caenorhabditis elegans |
sek-1(km4);glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
-4.46% |
32.1 |
33.6 |
|
mean |
25 |
℃ |
|
RNAi knockdown of cdc-25.1 in sek-1(km4);glp-4(bn2) had no significant effect on lifespan. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4837) |
18 |
OB_003417 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
clk-1 |
Caenorhabditis elegans |
175729 |
loss of function |
e2159 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-8.72% |
125.6 |
137.6 |
|
mean |
25 |
℃ |
|
Pathogen resistance is not linked with lifespan extension in aging mutants. Lifespan of clk-1(e2159) mutant was approximately 9% shorter than N2 control on cdc-25.1 background. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4842) |
19 |
OB_003410 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-30.55% |
69.8 |
100.5 |
|
mean |
25 |
℃ |
|
RNAi knockdown of cdc-25.1 Glp and daf-16 shortened lifespan approximately 30% in N2 animals. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4836) |
20 |
OB_003407 |
Caenorhabditis elegans |
glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-35.80% |
46.8 |
72.9 |
|
mean |
25 |
℃ |
|
Knock-down of daf-16 by RNA interference (RNAi) in glp-4(bn2) animals rendered these animals significantly more susceptible to PA14. Lifespan was approximately 34% shorter than control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4833) |
21 |
OB_003406 |
Caenorhabditis elegans |
rrf-3(pk1426);glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-49.85% |
34.1 |
68 |
|
mean |
25 |
℃ |
|
Knock-down of daf-16 by RNA interference (RNAi) in rrf-3(pk1426); glp-4(bn2) animals rendered these animals significantly more susceptible to PA14. Lifespan was approximately 50% shorter than control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4832) |