Other Ageing Factor: Dietary supplementation - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Other Ageing Factor Name | : | Dietary supplementation | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009199 | ||||||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||
1 | OB_008158 | Caenorhabditis elegans | N2 |
|
increased | 14.00% | 33.5 | 29.5 | day | maximum | hermaphrodite | Zarse et al. | 2012 | 22482728 | doi:10.1016/j.cmet.2012.02.013 | AgeFactDB Curator | |||||||||
2 | OB_008159 | Caenorhabditis elegans | N2 |
|
increased | 6.00% | 21.65 | 20.46 | day | mean | hermaphrodite | Zarse et al. | 2012 | 22482728 | doi:10.1016/j.cmet.2012.02.013 | AgeFactDB Curator | |||||||||
3 | OB_004978 | Caenorhabditis elegans | N2 |
|
none | 0.00% | 19.8 | 19.8 | days | mean | 20 | ℃ | Lifespan analysis of N2 animals grown on NGM plates and plates supplemented with cis-triglycerides showed no significant differences in lifespan. | Reisner et al. | 2011 | 21308896 | doi:10.1002/jbt.20386 | Lifespan Observations Database (ID: 5061) | |||||||
4 | OB_004981 | Caenorhabditis elegans | fat-3 (ok1126) |
|
none | -2.99% | 19.5 | 20.1 | days | mean | 20 | ℃ | In fat-3(ok1126) mutant worms there was not a significant difference in lifespan in cis-triglyceride fed animals compared to controls. | Reisner et al. | 2011 | 21308896 | doi:10.1002/jbt.20386 | Lifespan Observations Database (ID: 5064) | |||||||
5 | OB_004979 | Caenorhabditis elegans | N2 |
|
decreased | -8.08% | 18.2 | 19.8 | days | mean | 20 | ℃ | Lifespan analysis of N2 animals grown on NGM plates and plates supplemented with trans-triglycerides showed no significant differences in lifespan. | Reisner et al. | 2011 | 21308896 | doi:10.1002/jbt.20386 | Lifespan Observations Database (ID: 5062) | |||||||
6 | OB_004980 | Caenorhabditis elegans | fat-3 (ok1126) |
|
decreased | -27.86% | 14.5 | 20.1 | days | mean | 20 | ℃ | In fat-3 worms, a 30% decrease in life span was observed in trans-triglyceride fed animals compared to controls (20.1 4.9 (NGM), 19.5 5.3 (cis), and 14.5 6.7 (trans)). | Reisner et al. | 2011 | 21308896 | doi:10.1002/jbt.20386 | Lifespan Observations Database (ID: 5063) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Reisner K, Lehtonen M, Storvik M, Jantson T, Lakso M, Callaway JC, Wong G:
Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3.
J Biochem Mol Toxicol. 2011; 25: 269-79.
PubMed (ID: 21308896), doi:10.1002/jbt.20386
MeSH Terms: Caenorhabditis elegans/drug effects; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/metabolism; Fatty Acids, Unsaturated/metabolism; Gene Expression Regulation, Developmental/drug effects; Linoleoyl-CoA Desaturase/deficiency; Trans Fatty Acids/metabolism; Triglycerides/pharmacology - Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M:
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
Cell Metab. 2012; 15: 451-65.
PubMed (ID: 22482728), doi:10.1016/j.cmet.2012.02.013
MeSH Terms: Insulin-Like Growth Factor I/metabolism; Insulin/metabolism; Longevity/physiology; Mitochondria/metabolism; Proline/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- NCBI Taxonomy
- PubMed