Gene: MDM2 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
MDM2 |
NCBI Gene ID |
: |
4193 |
Species |
: |
Homo sapiens |
Gene Synonyms |
: |
|
Gene Homologs |
: |
MDM2 (Bos taurus) | MDM2 (Canis lupus familiaris) | mdm2 (Danio rerio) | MDM2 (Gallus gallus) | MDM2 (Homo sapiens) | MDM2 (Macaca mulatta) | Mdm2 (Mus musculus) | MDM2 (Pan troglodytes) | Mdm2 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_009212 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
E3 ubiquitin-protein ligase Mdm2 |
Homo sapiens |
Q00987 (UniProtKB/Swiss-Prot) |
MDM2_HUMAN (UniProtKB/Swiss-Prot) |
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation. |
View |
Observations
Ageing Phenotype
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008252 |
|
1 |
The HomoloGene homology group 1793 contains 1 gene with experimental evidence for ageing relevance (MDM2 - Homo sapiens) and 8 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 1793 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Momand J, Zambetti GP, Olson DC, George D, Levine AJ:
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.
Cell. 1992; 69: 1237-45.
PubMed (ID: 1535557)
MeSH Terms: Neoplasm Proteins/metabolism; Nuclear Proteins; Oncogene Proteins/metabolism; Proto-Oncogene Proteins; Transcriptional Activation/drug effects; Tumor Suppressor Protein p53/metabolism
- Das A, Chendil D, Dey S, Mohiuddin M, Mohiuddin M, Milbrandt J, Rangnekar VM, Ahmed MM:
Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.
J Biol Chem. 2001; 276: 3279-86.
PubMed (ID: 11035041), doi:10.1074/jbc.M008454200
MeSH Terms: Adaptor Proteins, Signal Transducing; Apoptosis; DNA-Binding Proteins/metabolism; Fibroblasts/metabolism; Immediate-Early Proteins; Nuclear Proteins; Transcription Factors/metabolism; Tumor Suppressor Protein p53/metabolism
- Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M:
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes Dev. 2001; 15: 1067-77.
PubMed (ID: 11331603), PubMed Central (ID: PMC312683), doi:10.1101/gad.886901
MeSH Terms: DNA Damage/physiology; Nuclear Proteins; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Tumor Suppressor Protein p53/metabolism
- Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, Perry ME:
mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.
Mol Cell Biol. 2003; 23: 462-72.
PubMed (ID: 12509446), PubMed Central (ID: PMC151546)
MeSH Terms: Gene Expression Regulation, Neoplastic; Lymphocytes/cytology; Nuclear Proteins; Proto-Oncogene Proteins/physiology; Tumor Suppressor Protein p53/metabolism
- Alt JR, Greiner TC, Cleveland JL, Eischen CM:
Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.
EMBO J. 2003; 22: 1442-50.
PubMed (ID: 12628936), PubMed Central (ID: PMC151074), doi:10.1093/emboj/cdg133
MeSH Terms: Genes, myc; Lymphoma, B-Cell/etiology; Lymphoma, B-Cell/genetics; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Nuclear Proteins; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism
- Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H:
Modulation of mammalian life span by the short isoform of p53.
Genes Dev. 2004; 18: 306-19.
PubMed (ID: 14871929), PubMed Central (ID: PMC338283), doi:10.1101/gad.1162404
MeSH Terms: Genes, p53; Longevity/genetics
- Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ:
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Cell. 2004; 119: 591-602.
PubMed (ID: 15550242), doi:10.1016/j.cell.2004.11.022
MeSH Terms: Cell Transformation, Neoplastic/genetics; Genetic Predisposition to Disease/genetics; Neoplasms/genetics; Nuclear Proteins/genetics; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins/genetics; Tumor Suppressor Protein p53/genetics
- Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM:
The antioxidant function of the p53 tumor suppressor.
Nat Med. 2005; 11: 1306-13.
PubMed (ID: 16286925), PubMed Central (ID: PMC2637821), doi:10.1038/nm1320
MeSH Terms: Apoptosis/physiology; DNA Damage; Gene Expression Regulation/physiology; Models, Biological; Reactive Oxygen Species/metabolism; Tumor Suppressor Protein p53/metabolism
- Mendrysa SM, O'Leary KA, McElwee MK, Michalowski J, Eisenman RN, Powell DA, Perry ME:
Tumor suppression and normal aging in mice with constitutively high p53 activity.
Genes Dev. 2006; 20: 16-21.
PubMed (ID: 16391230), PubMed Central (ID: PMC1356096), doi:10.1101/gad.1378506
MeSH Terms: Aging/metabolism; Intestinal Neoplasms/pathology; Proto-Oncogene Proteins c-mdm2/metabolism; Tumor Suppressor Protein p53/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources