Gene: GCLM - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | GCLM | ||||||||||||||||
NCBI Gene ID | : | 2730 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | |||||||||||||||||
Gene Homologs | : | AgaP_AGAP012038 (Anopheles gambiae) | E01A2.1 (Caenorhabditis elegans) | GCLM (Bos taurus) | GCLM (Canis lupus familiaris) | gclm (Danio rerio) | Gclm (Drosophila melanogaster) | GCLM (Gallus gallus) | GCLM (Homo sapiens) | Gclm (Mus musculus) | GCLM (Pan troglodytes) | Gclm (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_009228 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Glutamate--cysteine ligase regulatory subunit | Homo sapiens | P48507 (UniProtKB/Swiss-Prot) | GSH0_HUMAN (UniProtKB/Swiss-Prot) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009890 | Homo sapiens |
|
Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLM in fruit flies extended mean and maximum lifespan by up to 50% [1551]. In humans, polymorphisms in GCLM have been associated with myocardial infarction [1555]. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008210 | 2 | The HomoloGene homology group 1557 contains 2 genes with experimental evidence for ageing relevance (GCLM - Homo sapiens | Gclm - Drosophila melanogaster) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1557 |
Sequences
GSH0_HUMAN | P48507 | Glutamate--cysteine ligase regulatory subunit (Homo sapiens) from UniProtKB/Swiss-Prot Length: 274 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 GSH0_HUMAN 1 MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS 274
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Keogh BP, Allen RG, Pignolo R, Horton J, Tresini M, Cristofalo VJ:
Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages.
J Cell Physiol. 1996; 167: 512-22.
PubMed (ID: 8655605), doi:10.1002/(SICI)1097-4652(199606)167:3<512::AID-JCP15>3.0.CO;2-5
MeSH Terms: Aging/metabolism; Catalase/metabolism; Glutathione Peroxidase/metabolism; Glutathione/metabolism; Hydrogen Peroxide/metabolism; Skin/enzymology - Liu R, Choi J:
Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats.
Free Radic Biol Med. 2000; 28: 566-74.
PubMed (ID: 10719238)
MeSH Terms: Aging/metabolism; Gene Expression Regulation, Developmental; Glutamate-Cysteine Ligase/genetics - Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, Honda O, Yoshimura M, Ogawa H:
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
Circulation. 2002; 105: 2968-73.
PubMed (ID: 12081989)
MeSH Terms: 5' Flanking Region; Genetic Predisposition to Disease; Glutamate-Cysteine Ligase/genetics; Myocardial Infarction/genetics; Polymorphism, Genetic - Nakamura S, Sugiyama S, Fujioka D, Kawabata K, Ogawa H, Kugiyama K:
Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function.
Circulation. 2003; 108: 1425-7.
PubMed (ID: 12975258), doi:10.1161/01.CIR.0000091255.63645.98
MeSH Terms: Coronary Vessels/physiology; Glutamate-Cysteine Ligase/genetics; Nitric Oxide/metabolism; Polymorphism, Genetic; Vasomotor System/physiology - Brown-Borg HM, Rakoczy SG:
Glutathione metabolism in long-living Ames dwarf mice.
Exp Gerontol. 2005; 40: 115-20.
PubMed (ID: 15664737), doi:10.1016/j.exger.2004.11.004
MeSH Terms: Aging/metabolism; Glutathione/metabolism; Longevity - Orr WC, Radyuk SN, Prabhudesai L, Toroser D, Benes JJ, Luchak JM, Mockett RJ, Rebrin I, Hubbard JG, Sohal RS:
Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster.
J Biol Chem. 2005; 280: 37331-8.
PubMed (ID: 16148000), doi:10.1074/jbc.M508272200
MeSH Terms: Drosophila melanogaster/enzymology; Drosophila melanogaster/physiology; Glutamate-Cysteine Ligase/genetics; Glutamate-Cysteine Ligase/metabolism; Longevity/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot