Gene: BMH1 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
BMH1 |
NCBI Gene ID |
: |
856924 |
Species |
: |
Saccharomyces cerevisiae |
Gene Synonyms |
: |
|
Gene Homologs |
: |
AGOS_AGR107C (Eremothecium gossypii) | BMH1 (Saccharomyces cerevisiae) | BMH2 (Saccharomyces cerevisiae) | GRF3 (Arabidopsis thaliana) | GRF5 (Arabidopsis thaliana) | GRF7 (Arabidopsis thaliana) | KLLA0F12100g (Kluyveromyces lactis) | MGG_01588 (Magnaporthe oryzae) | NCU02806 (Neurospora crassa) | Os02g0580300 (Oryza sativa) | Os03g0710800 (Oryza sativa) | Os04g0462500 (Oryza sativa) | Os08g0430500 (Oryza sativa) | rad25 (Schizosaccharomyces pombe) | ywhae2 (Danio rerio) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_009240 |
Download |
: |
XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_007932 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
BMH1 |
856924 |
|
Other Ageing Factor Name |
Dietary restriction |
|
Deleting BMH1 extends chronological lifespan by 25% and is associated with activated stress response, decreased ROS levels and increased heat-shock-element-driven transcription activity. BMH1 deletion was non-additive with the genetic DR mimetic cdc25 and tor1. Water starvation (a form of extreme DR) extends chronological lifespan of BMH1 mutant even more as it does in wild-type. BMH1 genetically interacts with DR as well as TOR- and PKA-signaling pathways to regulate lifespan. Phosphorylation of Ser238 on Bmh1 increases during chronological aging, which is delayed by DR or reduced TOR activity [ 19805817]. |
19805817 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008365 |
|
2 |
The HomoloGene homology group 100743 contains 2 genes with experimental evidence for ageing relevance (BMH1 - Saccharomyces cerevisiae | BMH2 - Saccharomyces cerevisiae) and 13 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 100743 |
Sequences
no sequence information available
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wang C, Skinner C, Easlon E, Lin SJ:
Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response.
Genetics. 2009; 183: 1373-84.
PubMed (ID: 19805817), PubMed Central (ID: PMC2787426), doi:10.1534/genetics.109.107797
MeSH Terms: Gene Deletion; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology; Stress, Physiological/genetics
- Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD:
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
PLoS Genet. 2010; 6: e1001024.
PubMed (ID: 20657825), PubMed Central (ID: PMC2904796), doi:10.1371/journal.pgen.1001024
MeSH Terms: Genome, Fungal; Longevity/genetics; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
Additional Data Sources