Gene: RELA - Gallus gallus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | RELA | ||||||||||||
NCBI Gene ID | : | 396027 | ||||||||||||
Species | : | Gallus gallus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | dl (Drosophila melanogaster) | REL1 (Anopheles gambiae) | RELA (Bos taurus) | RELA (Canis lupus familiaris) | rela (Danio rerio) | RELA (Gallus gallus) | RELA (Homo sapiens) | RELA (Macaca mulatta) | Rela (Mus musculus) | Rela (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009515 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Transcription factor p65 | Gallus gallus | P98152 (UniProtKB/Swiss-Prot) | TF65_CHICK (UniProtKB/Swiss-Prot) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008165 |
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1 | The HomoloGene homology group 32064 contains 1 gene with experimental evidence for ageing relevance (RELA - Homo sapiens) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 32064 |
Sequences
TF65_CHICK | P98152 | Transcription factor p65 (Gallus gallus) from UniProtKB/Swiss-Prot Length: 558 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 TF65_CHICK 1 MEPADLLPLYLQPEWGEQEPGGATPFVEILEQPKQRGMRFRYKCEGRSAGSIPGEHSTDSARTHPTIRVNHYRGPGRVRVSLVTKDPPHGPHPHELVGRHCQHGYYEAELSPERCVHSFQNLGIQCVKKRELEAAVAERIRTNNNPFNVPMEERGAEYDLSAVRLCFQVWVNGPGGLCPLPPVLSQPIYDNRAPSTAELRILPGDRNSGSCQGGDEIFLLCDKVQKEDIEVRFWAEGWEAKGSFAAADVHRQVAIVFRTPPFRERSLRHPVTVRMELQRPSDRQRSPPLDFRYLPHQGDLQCIEEKRKRTRDTFRAFVQRAPLPGLEPNPEPRPPRRIAVPSRPPPAPQQPPSMVGAPPAPLFPLGVPPASSPTPEPLAEALLQLQFDDGVGGSGPPPSTTTTTTTTQCALGGGIPDPGGSPLDLGALLGDPPFDTIDAAELQRLLGPPETPPGGIGAGGGFGELLSLPTNFGDPPSSTAATFGPSPPMLLSYPEAITRLVQCQTPGGSGGGGPPVGPPQDLGGPLHPPGAPPQPTEDSLPSLGDLDFSAFLSQFPSS 558
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot