Gene: SUPT4H1 - Bos taurus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | SUPT4H1 | ||||||||||||
NCBI Gene ID | : | 616425 | ||||||||||||
Species | : | Bos taurus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP005428 (Anopheles gambiae) | MGG_06943 (Magnaporthe oryzae) | NCU03838 (Neurospora crassa) | spt-4 (Caenorhabditis elegans) | spt4 (Drosophila melanogaster) | Supt4a (Mus musculus) | SUPT4H1 (Bos taurus) | SUPT4H1 (Canis lupus familiaris) | supt4h1 (Danio rerio) | SUPT4H1 (Gallus gallus) | SUPT4H1 (Homo sapiens) | SUPT4H1 (Macaca mulatta) | SUPT4H1 (Pan troglodytes) | Supt4h1 (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009738 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Transcription elongation factor SPT4 | Bos taurus | Q3SYX6 (UniProtKB/Swiss-Prot) | SPT4H_BOVIN (UniProtKB/Swiss-Prot) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008199 | 1 | The HomoloGene homology group 68303 contains 1 gene with experimental evidence for ageing relevance (spt-4 - Caenorhabditis elegans) and 13 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 68303 |
Sequences
SPT4H_BOVIN | Q3SYX6 | Transcription elongation factor SPT4 (Bos taurus) from UniProtKB/Swiss-Prot Length: 117 10 20 30 40 50 60 70 80 90 100 110 SPT4H_BOVIN 1 MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT 117
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot