Gene: NCBP2_ANOGA - Anopheles gambiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | NCBP2_ANOGA | ||||||||||||
NCBI Gene ID | : | 3290635 | ||||||||||||
Species | : | Anopheles gambiae | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AGOS_AFL050W (Eremothecium gossypii) | CBC2 (Saccharomyces cerevisiae) | Cbp20 (Drosophila melanogaster) | KLLA0B10472g (Kluyveromyces lactis) | MGG_06296 (Magnaporthe oryzae) | ncbp-2 (Caenorhabditis elegans) | NCBP2 (Gallus gallus) | NCBP2_ANOGA (Anopheles gambiae) | NCU00210 (Neurospora crassa) | SPBC13A2.01c (Schizosaccharomyces pombe) | ||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||
Ageing Factor Stable ID | : | AF_010110 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Nuclear cap-binding protein subunit 2 | Anopheles gambiae | Q7QCB6 (UniProtKB/Swiss-Prot) | NCBP2_ANOGA (UniProtKB/Swiss-Prot) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008247 | 1 | The HomoloGene homology group 103828 contains 1 gene with experimental evidence for ageing relevance (ncbp-2 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 103828 |
Sequences
NCBP2_ANOGA | Q7QCB6 | Nuclear cap-binding protein subunit 2 (Anopheles gambiae) from UniProtKB/Swiss-Prot Length: 163 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 NCBP2_ANOGA 1 MSSQIQSVHTPSVSLSKYRDQHFKGSRHEQEKLLRVSSTLYVGNLSFYTTEEQIHELFSRCGDVRRIIMGLDKFKKTPCGFCFVEYYSRLDAESAMRYINGTRLDDRIVRVDWDAGFIEGRQYGRGKTGGQVRDEYRQDHDLGRGGYGKMVQMGQLGAPSMRE 163
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot