Gene: NCBP2 - Gallus gallus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | NCBP2 | ||||||||||||
NCBI Gene ID | : | 422214 | ||||||||||||
Species | : | Gallus gallus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AGOS_AFL050W (Eremothecium gossypii) | CBC2 (Saccharomyces cerevisiae) | Cbp20 (Drosophila melanogaster) | KLLA0B10472g (Kluyveromyces lactis) | MGG_06296 (Magnaporthe oryzae) | ncbp-2 (Caenorhabditis elegans) | NCBP2 (Gallus gallus) | NCBP2_ANOGA (Anopheles gambiae) | NCU00210 (Neurospora crassa) | SPBC13A2.01c (Schizosaccharomyces pombe) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_010111 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Nuclear cap-binding protein subunit 2 | Gallus gallus | Q5ZKR5 (UniProtKB/Swiss-Prot) | NCBP2_CHICK (UniProtKB/Swiss-Prot) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008247 | 1 | The HomoloGene homology group 103828 contains 1 gene with experimental evidence for ageing relevance (ncbp-2 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 103828 |
Sequences
NCBP2_CHICK | Q5ZKR5 | Nuclear cap-binding protein subunit 2 (Gallus gallus) from UniProtKB/Swiss-Prot Length: 168 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 NCBP2_CHICK 1 MSGLLHTTLSGLNSDSYCEISRYRDQHFRGSKKLQEKFLKISSTLYVGNLSFYTTEEQIQELFSKCGDVKRIVMGLDKIKKTPCGFCFVEYYTRADAEHAMRFINGTRLDDRIVRTDWDAGFKEGRQYGRGKTGGQVRDEYRTDYDVGRGGFGKIIQMQKANQQPAVY 168
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot