Gene: CISD2 - Bos taurus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | CISD2 | ||||||||||||
NCBI Gene ID | : | 781260 | ||||||||||||
Species | : | Bos taurus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP004484 (Anopheles gambiae) | CG1458 (Drosophila melanogaster) | CISD2 (Bos taurus) | cisd2 (Danio rerio) | CISD2 (Gallus gallus) | CISD2 (Homo sapiens) | Cisd2 (Mus musculus) | CISD2 (Pan troglodytes) | Cisd2 (Rattus norvegicus) | LOC100429989 (Macaca mulatta) | LOC100855477 (Canis lupus familiaris) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_010197 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
CDGSH iron-sulfur domain-containing protein 2 | Bos taurus | Q05B71 (UniProtKB/Swiss-Prot) | CISD2_BOVIN (UniProtKB/Swiss-Prot) | Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008255 | 2 | The HomoloGene homology group 36436 contains 2 genes with experimental evidence for ageing relevance (CISD2 - Homo sapiens | Cisd2 - Mus musculus) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 36436 |
Sequences
CISD2_BOVIN | Q05B71 | CDGSH iron-sulfur domain-containing protein 2 (Bos taurus) from UniProtKB/Swiss-Prot Length: 135 10 20 30 40 50 60 70 80 90 100 110 120 130 CISD2_BOVIN 1 MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV 135
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot