Gene: FEN1 - Gallus gallus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | FEN1 | ||||||||||||
NCBI Gene ID | : | 769677 | ||||||||||||
Species | : | Gallus gallus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP011448 (Anopheles gambiae) | crn-1 (Caenorhabditis elegans) | FEN1 (Arabidopsis thaliana) | FEN1 (Bos taurus) | FEN1 (Canis lupus familiaris) | Fen1 (Drosophila melanogaster) | FEN1 (Gallus gallus) | FEN1 (Homo sapiens) | FEN1 (Macaca mulatta) | Fen1 (Mus musculus) | FEN1 (Pan troglodytes) | Fen1 (Rattus norvegicus) | KLLA0F02992g (Kluyveromyces lactis) | MGG_03419 (Magnaporthe oryzae) | NCU10776 (Neurospora crassa) | Os05g0540100 (Oryza sativa) | rad2 (Schizosaccharomyces pombe) | RAD27 (Saccharomyces cerevisiae) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_011028 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Flap endonuclease 1 | Gallus gallus | Q5ZLN4 (UniProtKB/Swiss-Prot) | FEN1_CHICK (UniProtKB/Swiss-Prot) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008389 | 2 | The HomoloGene homology group 3034 contains 2 genes with experimental evidence for ageing relevance (FEN1 - Homo sapiens | RAD27 - Saccharomyces cerevisiae) and 16 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3034 |
Sequences
FEN1_CHICK | Q5ZLN4 | Flap endonuclease 1 (Gallus gallus) from UniProtKB/Swiss-Prot Length: 381 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 FEN1_CHICK 1 MGIHGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGAEVLQNEEGETTSHLMGMFYRTIRMVENGIKPVYVFDGKPPQLKSGELAKRTERRSEAEKHLQEAQEAGEEANIEKFSKRLVKVTQQHTDECKKLLMLMGIPYVEAPGEAEASCATLVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLNRVLQDLGLTWEQFVDLCILLGCDYCESIRGIGPKRAVELIKQHKTIEEIIQHIDTKKYPLPENWLHKEAQKLFLEPDVINPDDVELKWTEPNEEELVQFMCGEKQFNEERIRNGVKRLSKSRQGSTQGRLDDFFKVTGSITSAKRKEPETKGSAKKKAKTNSATAKFKKGK 381
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot