Gene: EIF5A2 - Gallus gallus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EIF5A2 | ||||||||||||
NCBI Gene ID | : | 396545 | ||||||||||||
Species | : | Gallus gallus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP011284 (Anopheles gambiae) | eIF-5A (Drosophila melanogaster) | EIF5A2 (Bos taurus) | EIF5A2 (Canis lupus familiaris) | eif5a2 (Danio rerio) | EIF5A2 (Gallus gallus) | EIF5A2 (Homo sapiens) | EIF5A2 (Macaca mulatta) | Eif5a2 (Mus musculus) | EIF5A2 (Pan troglodytes) | Eif5a2 (Rattus norvegicus) | iff-1 (Caenorhabditis elegans) | iff-2 (Caenorhabditis elegans) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_013207 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Eukaryotic translation initiation factor 5A-2 | Gallus gallus | Q07460 (UniProtKB/Swiss-Prot) | IF5A2_CHICK (UniProtKB/Swiss-Prot) | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008695 | 2 | The HomoloGene homology group 1490 contains 2 genes with experimental evidence for ageing relevance (Eif5a2 - Mus musculus | iff-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1490 |
Sequences
IF5A2_CHICK | Q07460 | Eukaryotic translation initiation factor 5A-2 (Gallus gallus) from UniProtKB/Swiss-Prot Length: 153 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 IF5A2_CHICK 1 MADELDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFNGKKYEDICPSTHNMDVPNIKRNDYQLIGIQDGYLSLLTESGEVREDLKLPEGDLGKEIEGKFNANEDVQISVISAMNEECAVAIKPCK 153
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot