Gene: TBP - Bos taurus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | TBP | ||||||||||||
NCBI Gene ID | : | 516578 | ||||||||||||
Species | : | Bos taurus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP010958 (Anopheles gambiae) | AGOS_AGR134W (Eremothecium gossypii) | KLLA0E10099g (Kluyveromyces lactis) | MGG_08878 (Magnaporthe oryzae) | NCU04770 (Neurospora crassa) | Os10g0432300 (Oryza sativa) | SPT15 (Saccharomyces cerevisiae) | TBP (Bos taurus) | TBP (Canis lupus familiaris) | tbp (Danio rerio) | Tbp (Drosophila melanogaster) | TBP (Gallus gallus) | TBP (Homo sapiens) | TBP (Macaca mulatta) | Tbp (Mus musculus) | TBP (Pan troglodytes) | Tbp (Rattus norvegicus) | tbp-1 (Caenorhabditis elegans) | tbp1 (Schizosaccharomyces pombe) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_014996 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
TATA-box-binding protein | Bos taurus | Q2HJ52 (UniProtKB/Swiss-Prot) | TBP_BOVIN (UniProtKB/Swiss-Prot) | General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008951 | 2 | The HomoloGene homology group 2404 contains 2 genes with experimental evidence for ageing relevance (TBP - Homo sapiens | tbp-1 - Caenorhabditis elegans) and 17 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2404 |
Sequences
TBP_BOVIN | Q2HJ52 | TATA-box-binding protein (Bos taurus) from UniProtKB/Swiss-Prot Length: 319 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 TBP_BOVIN 1 MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQAAVAAVQQSTSQQATQGPSGQTPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT 319
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot