Gene: EIF2S2 - Bos taurus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EIF2S2 | ||||||||||||
NCBI Gene ID | : | 520094 | ||||||||||||
Species | : | Bos taurus | ||||||||||||
Gene Synonyms | : | |||||||||||||
Gene Homologs | : | AgaP_AGAP007218 (Anopheles gambiae) | AGOS_AFL145W (Eremothecium gossypii) | eIF-2beta (Drosophila melanogaster) | EIF2 BETA (Arabidopsis thaliana) | EIF2S2 (Bos taurus) | EIF2S2 (Canis lupus familiaris) | eif2s2 (Danio rerio) | EIF2S2 (Gallus gallus) | EIF2S2 (Homo sapiens) | EIF2S2 (Macaca mulatta) | Eif2s2 (Mus musculus) | EIF2S2 (Pan troglodytes) | Eif2s2 (Rattus norvegicus) | iftb-1 (Caenorhabditis elegans) | KLLA0D08932g (Kluyveromyces lactis) | MGG_00789 (Magnaporthe oryzae) | NCU04640 (Neurospora crassa) | Os03g0333300 (Oryza sativa) | Os07g0681000 (Oryza sativa) | SUI3 (Saccharomyces cerevisiae) | tif212 (Schizosaccharomyces pombe) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_016477 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Eukaryotic translation initiation factor 2 subunit 2 | Bos taurus | Q5E9D0 (UniProtKB/Swiss-Prot) | IF2B_BOVIN (UniProtKB/Swiss-Prot) | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
IF2B_BOVIN | Q5E9D0 | Eukaryotic translation initiation factor 2 subunit 2 (Bos taurus) from UniProtKB/Swiss-Prot Length: 333 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 IF2B_BOVIN 1 MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEVEPEPTEDKDVEADEEDSRKKDASDDLDDLNFFNQKKKKKKSKKIFDIDEAEEGIKDLKIESDVQEPAEPEEDLDIMLGNKKKKKKVVKFPDEDEVLEKDEALEDEDSKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGRRAQLRAKAN 333
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- UniProtKB/Swiss-Prot