Ageing Phenotype Observation—Data Type 2 : OB_000008
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||||||||||
Strain | : | N2 | ||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | 29.88% | ||||||||||||||
Observed Lifespan | : | 31.3 | ||||||||||||||
Reference Lifespan | : | 24.1 | ||||||||||||||
Lifespan Unit | : | days | ||||||||||||||
Measure | : | mean | ||||||||||||||
Temperature | : | 20 | ||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||
Sex/Mating Type | : | hermaphrodite | ||||||||||||||
Description | : | Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 1007) | ||||||||||||||
Observation Stable ID | : | OB_000008 | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M:
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Science. 2009; 324: 1196-8.
PubMed (ID: 19372390), PubMed Central (ID: PMC2737476), doi:10.1126/science.1173507
MeSH Terms: Aging/physiology; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Cullin Proteins/metabolism; Oxygen/physiology; Proteasome Endopeptidase Complex/metabolism; Transcription Factors/metabolism