Ageing Phenotype Observation—Data Type 2 : OB_000016
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species |
: |
Caenorhabditis elegans |
Strain |
: |
N2 |
Gene |
: |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
Compound |
: |
|
Other Ageing Factor |
: |
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
Significant Lifespan Effect |
: |
increased |
Change |
: |
68.53% |
Observed Lifespan |
: |
39.1 |
Reference Lifespan |
: |
23.2 |
Lifespan Unit |
: |
days |
Measure |
: |
mean |
Temperature |
: |
20 |
Temperature Unit |
: |
℃ |
Sex/Mating Type |
: |
hermaphrodite |
Description |
: |
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. |
Observation Stable ID |
: |
OB_000016 |
Source |
: |
Lifespan Observations Database (ID: 1014) |
Download |
: |
XML |
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M:
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Science. 2009; 324: 1196-8.
PubMed (ID: 19372390), PubMed Central (ID: PMC2737476), doi:10.1126/science.1173507
MeSH Terms: Aging/physiology; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Cullin Proteins/metabolism; Oxygen/physiology; Proteasome Endopeptidase Complex/metabolism; Transcription Factors/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources