Ageing Phenotype Observation—Data Type 2 : OB_000023
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | |||||||||||||||||||||
Strain | : | N2 | |||||||||||||||||||||
Gene | : |
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Compound | : | ||||||||||||||||||||||
Other Ageing Factor | : | ||||||||||||||||||||||
Significant Lifespan Effect | : | decreased | |||||||||||||||||||||
Change | : | -10.05% | |||||||||||||||||||||
Observed Lifespan | : | 19.7 | |||||||||||||||||||||
Reference Lifespan | : | 21.9 | |||||||||||||||||||||
Lifespan Unit | : | days | |||||||||||||||||||||
Measure | : | mean | |||||||||||||||||||||
Temperature | : | 20 | |||||||||||||||||||||
Temperature Unit | : | ℃ | |||||||||||||||||||||
Sex/Mating Type | : | hermaphrodite | |||||||||||||||||||||
Description | : | Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. | |||||||||||||||||||||
Observation Stable ID | : | OB_000023 | |||||||||||||||||||||
Source | : | Lifespan Observations Database (ID: 1020) | |||||||||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M:
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Science. 2009; 324: 1196-8.
PubMed (ID: 19372390), PubMed Central (ID: PMC2737476), doi:10.1126/science.1173507
MeSH Terms: Aging/physiology; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Cullin Proteins/metabolism; Oxygen/physiology; Proteasome Endopeptidase Complex/metabolism; Transcription Factors/metabolism