Ageing Phenotype Observation—Data Type 2 : OB_000042
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | |||||||||||||||||||||
Strain | : | ||||||||||||||||||||||
Gene | : |
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Compound | : | ||||||||||||||||||||||
Other Ageing Factor | : | ||||||||||||||||||||||
Significant Lifespan Effect | : | decreased | |||||||||||||||||||||
Change | : | ||||||||||||||||||||||
Observed Lifespan | : | ||||||||||||||||||||||
Reference Lifespan | : | ||||||||||||||||||||||
Lifespan Unit | : | days | |||||||||||||||||||||
Measure | : | median | |||||||||||||||||||||
Temperature | : | ||||||||||||||||||||||
Temperature Unit | : | ||||||||||||||||||||||
Sex/Mating Type | : | female | |||||||||||||||||||||
Description | : | Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. | |||||||||||||||||||||
Observation Stable ID | : | OB_000042 | |||||||||||||||||||||
Source | : | Lifespan Observations Database (ID: 1038) | |||||||||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pendse AA, Johnson LA, Tsai YS, Maeda N:
Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
Diabetes. 2010; 59: 2890-7.
PubMed (ID: 20724579), PubMed Central (ID: PMC2963548), doi:10.2337/db10-0673
MeSH Terms: Adipose Tissue/metabolism; Hyperglycemia/genetics; Insulin Resistance/genetics; Mutation; PPAR gamma/genetics