Ageing Phenotype Observation—Data Type 2 : OB_000070
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Drosophila melanogaster | ||||||||||||||
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Gene | : |
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Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
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Observed Lifespan | : | |||||||||||||||
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Description | : | Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Other phenotypes: Mutation of chico results in life-span extension of up to 36% in heterozygous females. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [ 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [ 11292874]. | ||||||||||||||
Observation Stable ID | : | OB_000070 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 106) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L:
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
Science. 2001; 292: 104-6.
PubMed (ID: 11292874), doi:10.1126/science.1057991
MeSH Terms: Aging/physiology; Drosophila Proteins; Drosophila melanogaster/physiology; Insect Proteins/genetics; Insect Proteins/metabolism; Intracellular Signaling Peptides and Proteins; Longevity/physiology; Receptor Protein-Tyrosine Kinases; Receptor, Insulin/metabolism