Ageing Phenotype Observation—Data Type 2 : OB_000086
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species |
: |
Saccharomyces cerevisiae |
Strain |
: |
BY4742 |
Gene |
: |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
Compound |
: |
|
Other Ageing Factor |
: |
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Significant Lifespan Effect |
: |
increased |
Change |
: |
15.50% |
Observed Lifespan |
: |
29.8 |
Reference Lifespan |
: |
25.8 |
Lifespan Unit |
: |
divisions |
Measure |
: |
mean |
Temperature |
: |
30 |
Temperature Unit |
: |
℃ |
Sex/Mating Type |
: |
matalpha |
Description |
: |
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. |
Observation Stable ID |
: |
OB_000086 |
Source |
: |
Lifespan Observations Database (ID: 1086) |
Download |
: |
XML |
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK:
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science. 2005; 310: 1193-6.
PubMed (ID: 16293764), doi:10.1126/science.1115535
MeSH Terms: Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology
Sources
Ageing-related Data Sources
Additional Data Sources