Ageing Phenotype Observation—Data Type 2 : OB_000090
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Drosophila melanogaster | ||||||||||||||
Strain | : | |||||||||||||||
Gene | : |
|
||||||||||||||
Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | |||||||||||||||
Temperature | : | |||||||||||||||
Temperature Unit | : | |||||||||||||||
Sex/Mating Type | : | |||||||||||||||
Description | : | Flies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don''t overexpress the protein. Other phenotypes: Flies that overexpress MSRA retain reproductive capacity longer than parental controls that don''t overexpress the protein, and are more active, as measured by a climbing assay. | ||||||||||||||
Observation Stable ID | : | OB_000090 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 108) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, Heinemann SH:
High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
Proc Natl Acad Sci USA. 2002; 99: 2748-53.
PubMed (ID: 11867705), PubMed Central (ID: PMC122419), doi:10.1073/pnas.032671199
MeSH Terms: Longevity/physiology; Oxidoreductases/physiology