Ageing Phenotype Observation—Data Type 2 : OB_000094
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||
Strain | : | BY4742 | ||||||||||||||||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||||||||||||||||
Other Ageing Factor | : | |||||||||||||||||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||||||||||||||||
Change | : | 33.47% | ||||||||||||||||||||||||||||
Observed Lifespan | : | 32.7 | ||||||||||||||||||||||||||||
Reference Lifespan | : | 24.5 | ||||||||||||||||||||||||||||
Lifespan Unit | : | divisions | ||||||||||||||||||||||||||||
Measure | : | mean | ||||||||||||||||||||||||||||
Temperature | : | 30 | ||||||||||||||||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||||||||||||||||
Sex/Mating Type | : | matalpha | ||||||||||||||||||||||||||||
Description | : | Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. | ||||||||||||||||||||||||||||
Source | : | Lifespan Observations Database (ID: 1093) | ||||||||||||||||||||||||||||
Observation Stable ID | : | OB_000094 | ||||||||||||||||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK:
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science. 2005; 310: 1193-6.
PubMed (ID: 16293764), doi:10.1126/science.1115535
MeSH Terms: Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology