Ageing Phenotype Observation—Data Type 2 : OB_000098
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Saccharomyces cerevisiae | ||||||||||||||
Strain | : | S150-2B | ||||||||||||||
Gene | : |
|
||||||||||||||
Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | decreased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | |||||||||||||||
Temperature | : | |||||||||||||||
Temperature Unit | : | |||||||||||||||
Sex/Mating Type | : | |||||||||||||||
Description | : | Deletion of PHB1 results in approximately 20% shorter lifespan. Other phenotypes: Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [ 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant, and a slight defect in the phb1 single mutant. Deletion of PHB1 is synthetically lethal [ 9259555]. | ||||||||||||||
Observation Stable ID | : | OB_000098 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 10) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA:
The prohibitin family of mitochondrial proteins regulate replicative lifespan.
Curr Biol. 1997; 7: 607-10.
PubMed (ID: 9259555)
MeSH Terms: Cell Aging/physiology; Mitochondria/physiology; Proteins/physiology; Repressor Proteins