Ageing Phenotype Observation—Data Type 2 : OB_000120
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Mus musculus | ||||||||||||||
Strain | : | 129Ola and BalbC | ||||||||||||||
Gene | : |
|
||||||||||||||
Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | |||||||||||||||
Temperature | : | |||||||||||||||
Temperature Unit | : | |||||||||||||||
Sex/Mating Type | : | |||||||||||||||
Description | : | Mice homozygous for disruption of GHR/BP have a life-span that is 40-50% longer than wild type or heterozygous mice. Other phenotypes: The GHR/BP knockout mouse is a model for the rare human disease Laron syndrome [ 9371826]. Serum levels of GH are elevated in mutant mice [ 9371826]. Mutant mice are smaller than wild type mice. IGF-I and IGFBP-3 levels are also reduc | ||||||||||||||
Observation Stable ID | : | OB_000120 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 112) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ:
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.
Endocrinology. 2000; 141: 2608-13.
PubMed (ID: 10875265)
MeSH Terms: Carrier Proteins/genetics; Gene Deletion; Longevity/genetics; Receptors, Somatotropin/genetics