Ageing Phenotype Observation—Data Type 2 : OB_000518
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Podospora anserina | ||||||||||||||
Strain | : | s | ||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
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Sex/Mating Type | : | |||||||||||||||
Description | : | Deletion of mobile group II intron (intron alpha) from COX1 doubled lifespan. Other phenotypes: Deletion encompassing intron alpha and its upstream exon abolished the senescence process entirely [ 2999848]. Deletion of the PaCOX1 intron-alpha prevented accumulation of senescence-associated DNA concatemer corresponding to this region of the mitochondrial genome [ 10330149]. | ||||||||||||||
Observation Stable ID | : | OB_000518 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 177) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Begel O, Boulay J, Albert B, Dufour E, Sainsard-Chanet A:
Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina.
Mol Cell Biol. 1999; 19: 4093-100.
PubMed (ID: 10330149), PubMed Central (ID: PMC104368)
MeSH Terms: Ascomycota/physiology; DNA, Mitochondrial/genetics; Electron Transport Complex IV/physiology; Introns/physiology