Ageing Phenotype Observation—Data Type 2 : OB_002020
Last modified: Dec 09, 2014. Release 1 • Page created: Sep 21, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||
Strain | : | N2 | ||||||||||||||||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||||||||||||||||
Other Ageing Factor | : | |||||||||||||||||||||||||||||
Significant Lifespan Effect | : | decreased | ||||||||||||||||||||||||||||
Change | : | -26.53% | ||||||||||||||||||||||||||||
Observed Lifespan | : | 10.8 | ||||||||||||||||||||||||||||
Reference Lifespan | : | 14.7 | ||||||||||||||||||||||||||||
Lifespan Unit | : | days | ||||||||||||||||||||||||||||
Measure | : | median | ||||||||||||||||||||||||||||
Temperature | : | 25 | ||||||||||||||||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||||||||||||||||
Sex/Mating Type | : | hermaphrodite | ||||||||||||||||||||||||||||
Description | : | A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. | ||||||||||||||||||||||||||||
Observation Stable ID | : | OB_002020 | ||||||||||||||||||||||||||||
Source | : | Lifespan Observations Database (ID: 3318) | ||||||||||||||||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Samuelson AV, Carr CE, Ruvkun G:
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes Dev. 2007; 21: 2976-94.
PubMed (ID: 18006689), PubMed Central (ID: PMC2049198), doi:10.1101/gad.1588907
MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology