Ageing Phenotype Observation—Data Type 2 : OB_002602
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||||||||||
Strain | : | N2 | ||||||||||||||
Gene | : |
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Compound | : |
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Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | 64.07% | ||||||||||||||
Observed Lifespan | : | 27.4 | ||||||||||||||
Reference Lifespan | : | 16.7 | ||||||||||||||
Lifespan Unit | : | days | ||||||||||||||
Measure | : | mean | ||||||||||||||
Temperature | : | 20 | ||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||
Sex/Mating Type | : | hermaphrodite | ||||||||||||||
Description | : | The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 3889) | ||||||||||||||
Observation Stable ID | : | OB_002602 | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Evason K, Huang C, Yamben I, Covey DF, Kornfeld K:
Anticonvulsant medications extend worm life-span.
Science. 2005; 307: 258-62.
PubMed (ID: 15653505), doi:10.1126/science.1105299
MeSH Terms: Aging/drug effects; Anticonvulsants/pharmacology; Caenorhabditis elegans/drug effects; Ethosuximide/pharmacology; Lactams/pharmacology; Longevity/drug effects; Trimethadione/pharmacology