Ageing Phenotype Observation—Data Type 2 : OB_002829
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||||||||||
Strain | : | N2 | ||||||||||||||
Gene | : |
|
||||||||||||||
Compound | : |
|
||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | 12.50% | ||||||||||||||
Observed Lifespan | : | 16.2 | ||||||||||||||
Reference Lifespan | : | 14.4 | ||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | mean | ||||||||||||||
Temperature | : | 20 | ||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||
Sex/Mating Type | : | hermaphrodite | ||||||||||||||
Description | : | Oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO DAF-16, and the energy sensor, AMP-activated protein kinase. | ||||||||||||||
Observation Stable ID | : | OB_002829 | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 4118) | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Williams DS, Cash A, Hamadani L, Diemer T:
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.
Aging Cell. 2009; 8: 765-8.
PubMed (ID: 19793063), PubMed Central (ID: PMC2988682), doi:10.1111/j.1474-9726.2009.00527.x
MeSH Terms: AMP-Activated Protein Kinases/metabolism; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Forkhead Transcription Factors/metabolism; Longevity; Oxaloacetates/metabolism; Signal Transduction