Ageing Phenotype Observation—Data Type 2 : OB_003094
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Saccharomyces cerevisiae | ||||||||||||||
Strain | : | YPK9 | ||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : |
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Significant Lifespan Effect | : | decreased | ||||||||||||||
Change | : | -27.20% | ||||||||||||||
Observed Lifespan | : | 9.1 | ||||||||||||||
Reference Lifespan | : | 12.5 | ||||||||||||||
Lifespan Unit | : | divisions | ||||||||||||||
Measure | : | mean | ||||||||||||||
Temperature | : | 30 | ||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||
Sex/Mating Type | : | mata | ||||||||||||||
Description | : | Combining deletion of the histone deacetylase SIR2 with dietary restriction by reducing media glucose from 2% to 0.1% reduces lifespan by 27.2%. Deletion of SIR2 did not prevent lifespan extension from glucose restriction. | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 4473) | ||||||||||||||
Observation Stable ID | : | OB_003094 | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Jiang JC, Wawryn J, Shantha Kumara HM, Jazwinski SM:
Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast.
Exp Gerontol. 2002; 37: 1023-30.
PubMed (ID: 12213553)
MeSH Terms: Fungal Proteins/physiology; Histone Deacetylases/physiology; Repressor Proteins; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/physiology; Transcription Factors