Ageing Phenotype Observation—Data Type 2 : OB_003572
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||||||||||
Strain | : | trx-1(ok1449);eat-2(ad1116) | ||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | decreased | ||||||||||||||
Change | : | -13.00% | ||||||||||||||
Observed Lifespan | : | 13 | ||||||||||||||
Reference Lifespan | : | 13 | ||||||||||||||
Lifespan Unit | : | days | ||||||||||||||
Measure | : | median | ||||||||||||||
Temperature | : | 20 | ||||||||||||||
Temperature Unit | : | ℃ | ||||||||||||||
Sex/Mating Type | : | |||||||||||||||
Description | : | The inability of trx-1(ok1449) eat-2(ad1116) double mutants to extend lifespan was rescued by expression of Ptrx-1::trx-1::GFP in ASJ neurons. This rescue was not achieved in the same genetic background when trx-1::GFP was expressed from the ges-1 promoter in the intestine. Median lifespan of transgenic worms, expressed in the intestine, was not significantly different than control. | ||||||||||||||
Source | : | Lifespan Observations Database (ID: 5007) | ||||||||||||||
Observation Stable ID | : | OB_003572 | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Fierro-González JC, González-Barrios M, Miranda-Vizuete A, Swoboda P:
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
Biochem Biophys Res Commun. 2011; 406: 478-82.
PubMed (ID: 21334311), doi:10.1016/j.bbrc.2011.02.079
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Diet; Longevity; Neurons/metabolism; Thioredoxins/physiology