Ageing Phenotype Observation—Data Type 2 : OB_004238
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species |
: |
Saccharomyces cerevisiae |
Strain |
: |
BY4742 |
Gene |
: |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pex5 |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
Compound |
: |
|
Other Ageing Factor |
: |
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reducing the glucose concentration of the medium from 2% to 0.5%. |
|
Significant Lifespan Effect |
: |
decreased |
Change |
: |
-50.00% |
Observed Lifespan |
: |
5 |
Reference Lifespan |
: |
10 |
Lifespan Unit |
: |
days |
Measure |
: |
mean |
Temperature |
: |
30 |
Temperature Unit |
: |
℃ |
Sex/Mating Type |
: |
matalpha |
Description |
: |
Reducing the glucose concentration of the synthetic defined culture medium from 2% to 0.5% significantly decreased the chronological life span of cells deleted for PEX5, in contrast to increasing the life span of wild type cells. |
Observation Stable ID |
: |
OB_004238 |
Source |
: |
Lifespan Observations Database (ID: 934) |
Download |
: |
XML |
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI:
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Aging (Albany NY). 2010; 2: 393-414.
PubMed (ID: 20622262), PubMed Central (ID: PMC2933888)
MeSH Terms: Lithocholic Acid/physiology; Longevity/genetics; Models, Genetic; Yeasts/physiology
Sources
Ageing-related Data Sources
Additional Data Sources