Ageing Phenotype Observation—Data Type 2 : OB_004346
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||||
Strain | : | UM-HET3 | ||||||
Gene | : | |||||||
Compound | : |
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Other Ageing Factor | : | |||||||
Significant Lifespan Effect | : | none | ||||||
Change | : | 0.00% | ||||||
Observed Lifespan | : | 920 | ||||||
Reference Lifespan | : | 920 | ||||||
Lifespan Unit | : | days | ||||||
Measure | : | median | ||||||
Temperature | : | |||||||
Temperature Unit | : | |||||||
Sex/Mating Type | : | female | ||||||
Description | : | A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice. | ||||||
Observation Stable ID | : | OB_004346 | ||||||
Source | : | Lifespan Observations Database (ID: 2273) | ||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Flurkey K, Astle CM, Harrison DE:
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.
J Gerontol A Biol Sci Med Sci. 2010; 65: 1275-84.
PubMed (ID: 20819793), PubMed Central (ID: PMC2990268), doi:10.1093/gerona/glq155
MeSH Terms: Acetylcysteine/pharmacology; Crosses, Genetic; Diet; Life Expectancy; Mice, Inbred Strains/genetics