Ageing Phenotype Observation—Data Type 2 : OB_004367
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||
Strain | : | N2 | ||||||
Gene | : | |||||||
Compound | : |
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Other Ageing Factor | : | |||||||
Significant Lifespan Effect | : | increased | ||||||
Change | : | 24.42% | ||||||
Observed Lifespan | : | 27 | ||||||
Reference Lifespan | : | 21.7 | ||||||
Lifespan Unit | : | days | ||||||
Measure | : | mean | ||||||
Temperature | : | 20 | ||||||
Temperature Unit | : | ℃ | ||||||
Sex/Mating Type | : | hermaphrodite | ||||||
Description | : | 0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. | ||||||
Source | : | Lifespan Observations Database (ID: 2470) | ||||||
Observation Stable ID | : | OB_004367 | ||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wang X, Wang X, Li L, Wang D:
Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16.
Biochem Biophys Res Commun. 2010; 400: 613-8.
PubMed (ID: 20828537), doi:10.1016/j.bbrc.2010.08.113
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/drug effects; Dimethyl Sulfoxide/pharmacology; Longevity/drug effects; Sirtuins/physiology; Solvents/pharmacology; Transcription Factors/physiology