Ageing Phenotype Observation—Data Type 2 : OB_004701
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||||
Strain | : | N2 | ||||||
Gene | : | |||||||
Compound | : |
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Other Ageing Factor | : | |||||||
Significant Lifespan Effect | : | increased | ||||||
Change | : | 25.44% | ||||||
Observed Lifespan | : | 23.57 | ||||||
Reference Lifespan | : | 18.79 | ||||||
Lifespan Unit | : | days | ||||||
Measure | : | mean | ||||||
Temperature | : | 20 | ||||||
Temperature Unit | : | ℃ | ||||||
Sex/Mating Type | : | |||||||
Description | : | Metformin increased lifespan to a similar degree in the absence (25%) or presence of carbenicillin (24%). Thus, metformin does not increase lifespan by preventing bacterial proliferation. | ||||||
Source | : | Lifespan Observations Database (ID: 5385) | ||||||
Observation Stable ID | : | OB_004701 | ||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D:
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cell. 2013; 153: 228-39.
PubMed (ID: 23540700), doi:10.1016/j.cell.2013.02.035
MeSH Terms: Caenorhabditis elegans/drug effects; Caenorhabditis elegans/microbiology; Folic Acid/metabolism; Hypoglycemic Agents/pharmacology; Longevity/drug effects; Metformin/pharmacology; Methionine/metabolism