Ageing Phenotype Observation—Data Type 1 : OB_005380
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Knockdown of HSP-6 by RNAi in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP level. As a result, RNAi-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material and a shorter lifespan (15% reduction). | ||||
PubMed | : | 17189267 | ||||
Observation Stable ID | : | OB_005380 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S:
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
J Biol Chem. 2007; 282: 5910-8.
PubMed (ID: 17189267), doi:10.1074/jbc.M609025200
MeSH Terms: Caenorhabditis elegans/genetics; HSP70 Heat-Shock Proteins/deficiency; Longevity/genetics; Mitochondrial Proteins/deficiency; Oogenesis/genetics