Ageing Phenotype Observation—Data Type 1 : OB_005407
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Loss of a specific eIF4E isoform (IFE-2) that functions in somatic tissues reduces global protein synthesis, protects from oxidative stress and extends maximum lifespan by 30% in C. elegans. Lifespan extension is independent of the forkhead transcription factor DAF-16, which mediates the effects of the insulin-like signalling pathway on ageing. Furthermore, IFE-2 deficiency further extends the lifespan of long-lived age (30%) and daf (15% maximum lifespan) nematode mutants. Knockdown of ife-2 extends the lifespan (50% maximum lifespan) of glp-4(bn2) mutant animals lacking a germ line. Similarly, lack of IFE-2 enhances the long-lived phenotype of clk (30% maximum lifespan) and dietary-restricted eat mutant animals (30% maximum lifespan). Knockdown of target of rapamycin (TOR), a phosphatidylinositol kinase that controls protein synthesis in response to nutrient cues, further increases the longevity of ife-2 mutants (10-15% maximum lifespan). Depletion of other eIF4E isoforms had no effect on longevity. | ||||
PubMed | : | 17277769 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005407 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Syntichaki P, Troulinaki K, Tavernarakis N:
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
Nature. 2007; 445: 922-6.
PubMed (ID: 17277769), doi:10.1038/nature05603
MeSH Terms: Aging/physiology; Caenorhabditis elegans/cytology; Caenorhabditis elegans/physiology; Eukaryotic Initiation Factor-4E/metabolism; Longevity/physiology