Ageing Phenotype Observation—Data Type 1 : OB_005415
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Inhibition of ifg-1 during adulthood led to a 36% increase in maximum lifespan. Inhibition of at least one eIF4E isoform and two of the three poly(A)-binding proteins also has a significant effect on lifespan extension. Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%. | ||||
PubMed | : | 17266680 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005415 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P:
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
Aging Cell. 2007; 6: 111-9.
PubMed (ID: 17266680), PubMed Central (ID: PMC2745345), doi:10.1111/j.1474-9726.2006.00266.x
MeSH Terms: Caenorhabditis elegans Proteins/biosynthesis; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Gene Expression Regulation, Developmental/genetics; Longevity/genetics; Protein Biosynthesis/genetics; Ribosomal Protein S6 Kinases, 70-kDa/biosynthesis