Ageing Phenotype Observation—Data Type 1 : OB_005423
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Mice heterozygous for IGF1R live 26% longer than controls. Female Igf1r +/- mice live 33% longer, while male mice live 16% longer. Igf1r +/- mice have normal size, normal metabolism, normal nutrient uptake, fertility and reproduction, and seem to be oxidative stress resistant. | ||||
PubMed | : | 12483226 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005423 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y:
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Nature. 2003; 421: 182-7.
PubMed (ID: 12483226), doi:10.1038/nature01298
MeSH Terms: Longevity/genetics; Oxidative Stress/genetics; Receptor, IGF Type 1/metabolism