Ageing Phenotype Observation—Data Type 1 : OB_005424
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
|
||||
Other Ageing Factor | : | |||||
Description | : | Nearly 40% mean lifespan extension in heterozygotes knockout, however, the maximum lifespan was unchanged. Homozygotes KO mice showed the same average lifespan as controls. | ||||
PubMed | : | 18959478 | ||||
Observation Stable ID | : | OB_005424 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kappeler L, De Magalhaes Filho C, Dupont J, Leneuve P, Cervera P, Périn L, Loudes C, Blaise A, Klein R, Epelbaum J, Le Bouc Y, Holzenberger M:
Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.
PLoS Biol. 2008; 6: e254.
PubMed (ID: 18959478), PubMed Central (ID: PMC2573928), doi:10.1371/journal.pbio.0060254
MeSH Terms: Brain/metabolism; Longevity/physiology; Neurosecretory Systems/metabolism; Receptor, IGF Type 1/physiology