Ageing Phenotype Observation—Data Type 1 : OB_005438
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Homologous murine model was created by replacing Pro-1195 of insulin receptors with Leu. Homozygous mice died in the neonatal stage from diabetic ketoacidosis, whereas heterozygous mice showed the suppressed kinase activity of the insulin receptor but grew normally without spontaneously developing diabetes during adulthood. Under 80% oxygen, mutant female mice survived 33.3% longer than wild-type female mice, whereas mutant male mice survived 18.2% longer than wild-type male mice. | ||||
PubMed | : | 15713666 | ||||
Observation Stable ID | : | OB_005438 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Baba T, Shimizu T, Suzuki Y, Ogawara M, Isono K, Koseki H, Kurosawa H, Shirasawa T:
Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice.
J Biol Chem. 2005; 280: 16417-26.
PubMed (ID: 15713666), doi:10.1074/jbc.M500924200
MeSH Terms: Estrogens/metabolism; Insulin/metabolism; Longevity/physiology; Oxidative Stress/physiology; Receptor, Insulin/genetics